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JWG-071

Name: JWG-071
Brand: TargetMol
SKU: T14547
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14547Cas No. 2250323-50-1

Alias JWG071, JWG 071

JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity.

JWG-071

🥰Excellent

Purity: 98.33%

Catalog No. T14547Alias JWG071, JWG 071Cas No. 2250323-50-1

JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity.

Pack Size	Price	Availability
1 mg	$61	In Stock
5 mg	$147	In Stock
10 mg	$185	In Stock
25 mg	$282	In Stock
50 mg	$419	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Purity:98.33%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity.
Targets&IC50	ERK5:88 nM
In vitro	JWG-071 demonstrates IC50 values of 88 nM and 109 nM for inhibiting ERK5 and LRRK2, respectively.[1]
Synonyms	JWG071, JWG 071

Chemical Properties

Molecular Weight	612.77
Formula	C₃₄H₄₄N₈O₃
Cas No.	2250323-50-1
Smiles	CCC(C)N1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3OC)C(=O)N3CCC(CC3)N3CCN(C)CC3)nc12
Relative Density.	1.238 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 61.28 mg/mL (100 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6319 mL	8.1597 mL	16.3193 mL	81.5967 mL
5 mM	0.3264 mL	1.6319 mL	3.2639 mL	16.3193 mL
10 mM	0.1632 mL	0.8160 mL	1.6319 mL	8.1597 mL
20 mM	0.0816 mL	0.4080 mL	0.8160 mL	4.0798 mL
50 mM	0.0326 mL	0.1632 mL	0.3264 mL	1.6319 mL
100 mM	0.0163 mL	0.0816 mL	0.1632 mL	0.8160 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc