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HDAC6-IN-10

Name: HDAC6-IN-10
Brand: TargetMol
SKU: T61792
Rating: 4.5 (1 reviews)

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HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Furthermore, HDAC6-IN-10 exhibits notable anti-proliferative effects on multiple myeloma cells [1].

Cas No. 2408286-73-5

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Furthermore, HDAC6-IN-10 exhibits notable anti-proliferative effects on multiple myeloma cells [1].
Targets & IC50	HDAC7:752 nM, HDAC5:4370 nM, HDAC1:8020 nM, HDAC9:2560 nM, HDAC8:513 nM, HDAC11:1800 nM, HDAC6:0.73 nM, HDAC10:105 nM, HDAC4:5620 nM
In vitro	HDAC6-IN-10 (Compound 21b) demonstrates high specificity for inhibiting HDAC6 when administered at 0.1 to 10 μM over 24 hours [1]. At 0 to 100 μM over 72 hours, it exerts anti-proliferative effects on multiple myeloma cell lines RPMI-8226 and U266 [1]. In HCT-116 Western Blot analyses with 0.1, 1, and 10 μM over 24 hours, a dose-dependent increase in Ac-tubulin levels was observed. Cell Proliferation Assays showed inhibition of RPMI-8226 and U266 cell growth, with IC 50 values of 33.183 μM and 43.233 μM, respectively [1].

Chemical Properties

Molecular Weight	392.41
Formula	C₂₁H₂₀N₄O₄
Cas No.	2408286-73-5
Smiles	C(C=1C=2C(NC1)=CC=CC2)[C@@H]3C(=O)N(CC4=CC=C(C(NO)=O)C=C4)CC(=O)N3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: HDAC6-IN-10 chemical structure | HDAC6-IN-10 in vitro | HDAC6-IN-10 formula | HDAC6-IN-10 molecular weight