Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Furthermore, HDAC6-IN-10 exhibits notable anti-proliferative effects on multiple myeloma cells [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Furthermore, HDAC6-IN-10 exhibits notable anti-proliferative effects on multiple myeloma cells [1]. |
In vitro | HDAC6-IN-10 (Compound 21b) demonstrates high specificity for inhibiting HDAC6 when administered between 0.1 to 10 μM over 24 hours [1]. Additionally, when applied at concentrations ranging from 0 to 100 μM for 72 hours, this compound exerts anti-proliferative effects on two multiple myeloma cell lines, RPMI-8226 and U266 [1]. In Western Blot Analyses conducted on the HCT-116 cell line with concentrations of 0.1, 1, and 10 μM over 24 hours, a dose-dependent increase in Ac-tubulin levels was observed. Similarly, Cell Proliferation Assays revealed that HDAC6-IN-10 inhibits the growth of RPMI-8226 and U266 cells within the same concentration and incubation timeframe, achieving IC 50 values of 33.183 μM and 43.233 μM, respectively [1]. |
Molecular Weight | 392.41 |
Formula | C21H20N4O4 |
CAS No. | 2408286-73-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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HDAC6-IN-10 2408286-73-5 inhibitor inhibit