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TargetMol | Compound Library

Anti-Hypertension Compound Library

Catalog No. L7110

Hypertension (hypertension) is a clinical syndrome characterized by increased arterial blood pressure (systolic and/or diastolic) in the body circulation (systolic blood pressure ≥ 140 mm Hg and diastolic blood pressure ≥ 90 mm Hg), often accompanied by clinical syndromes including metabolic disorders of fat and glucose, functional or organic changes in the heart, brain, kidney, and retina. Hypertension is the most common chronic disease and is the most important risk factor for cardiovascular and cerebrovascular diseases. The results of several studies suggest that intervention of blood pressure, early prevention and treatment of hypertension can help reduce the risk of cardiovascular disease. Drugs for the treatment of hypertension are divided into five main categories. 1. Angiotensin-converting enzyme inhibitor (ACEI): Their mechanism of action is mainly based on the inhibition of the angiotensin-converting enzyme so that the secretion of angiotensin, aldosterone and vasopressin is reduced. The reduction of these substances can cause a series of effects such as vasodilation, reduction of vascular peripheral resistance, increase of water and sodium discharge, and reduction of blood volume, thus bringing down blood pressure. In addition, ACEI drugs have the effect of blocking the hydrolysis of bradykinin, which can increase the concentration of bradykinin as well as the secretion of prostaglandins that effectively dilate blood vessels and lower blood pressure. Examples include Captopril, Enalapril, Fosinopril, Lisinopril, etc. 2. Angiotensin receptor antagonist (ARB): Their mechanism of action is similar to that of ACEI, which inhibits the secretion of angiotensin and lowers blood pressure. ARB drugs are widely favored because unlike ACEI drugs, they do not lead to hacking cough. Examples of ARB drugs include Valsartan, Losartan, Telmisartan, Irbesartan, etc. 3. β-receptor antagonist: Their Anti-hypertension mechanism is mainly based on the reduction of cardiac blood output, where the body produces an adaptive response, causing a reduction in peripheral vascular resistance and blood pressure. At the same time, the β-receptors are blocked, sympathetic nerve fiber nerve conduction is reduced, and the release of norepinephrine is decreased, thus the blood pressure is further decreased. Examples of β-receptor antagonist drugs include Atenolol, Metoprolol, Bisoprolol, Carvedilol, etc. 4. Calcium Chanel Blocker (CCB): They mainly prevent the transfer of calcium ions from extracellular to intracellular, so that the intracellular calcium ion concentration is reduced, thus reducing the contractility of cardiomyocytes, and also reducing the excitability of the sinoatrial node and the conduction of the atrioventricular node, achieving a decrease in blood pressure. In addition, CCB drugs have a powerful effect of dilating small arterial vessels. Examples of CCB drugs include nifedipine, amlodipine, etc. 5.diuretics: these drugs affect the kidney mainly by diuretic sodium excretion that reduces the extracellular volume and decreases peripheral vascular resistance. Therefore, the Anti-hypertension effect of this class of drugs is smooth and slow, with a relatively long duration. According to drug classification, there are thiazide diuretics such as hydrochlorothiazide, tab diuretics such as furosemide, and potassium-protective diuretics such as spironolactone. TargetMol Anti-hypertension Compound Library is a collection of 524 hypertension-related small molecules, including compounds with Anti-hypertension effects and compounds that act on hypertension-related targets, that support your research or related drug screening.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L7110

Anti-Hypertension Compound Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • 678 hypertension-related small molecules for high-throughput and high-content screening.
  • Targets include ACE, calcium channel, β-adrenergic receptor, HMG-CoA Reductase, etc.
  • Detailed instructions, compound structure, target information, activity description, etc.
  • NMR and HPLC analytical techniques to ensure high product purity and quality.
  • All compounds are available in stock.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Adrenergic Receptor
Calcium Channel
Autophagy
Dopamine Receptor
RAAS
PPAR
5-HT Receptor
Apoptosis
AMPK
Endogenous Metabolite
Potassium Channel
P450
AChR
Histone Acetyltransferase
HMG-CoA Reductase
Histamine Receptor
Antibacterial
Epigenetic Reader Domain
Prostaglandin Receptor
BACE
NF-κB
Sodium Channel
Ferroptosis
COX
Influenza Virus
PDE
Endothelin Receptor
Acetyl-CoA Carboxylase
Parasite
Beta-Secretase
Carbonic Anhydrase
Mitophagy
Reactive Oxygen Species
P-gp
Norepinephrine
Antibiotic
Antifungal
ROCK
Glucocorticoid Receptor
CaMK
ATPase
TRP/TRPV Channel
MRP
GABA Receptor
Adenosine Receptor
VEGFR
iGluR
PKC
Guanylate cyclase
Opioid Receptor
TGF-beta/Smad
Nrf2
STAT
HIV Protease
PI3K
PKA
MAO
SIK
Drug Metabolite
Monoamine Transporter
MMP
Akt
AChE
Neprilysin
Beta Amyloid
TNF
RSV
Hydroxylase
Anti-infection
Tyrosinase
Thrombin
Imidazoline Receptor
Monoamine Oxidase
Chloride channel
Histone Methyltransferase
Src
Arrestin
Phosphatase
ABC
Virus Protease
Wnt/beta-catenin
PARP
LDL
NMDAR
Serotonin Transporter
ERK
Na-K-Cl cotransporter
Fatty Acid Synthase
IL Receptor
Bradykinin Receptor
GluR
Lipoxygenase
Interleukin
EGFR
DNA/RNA Synthesis
transporter
Androgen Receptor
Aminopeptidase
NO Synthase
HDAC
Reductase
RAR/RXR 
NADPH
JNK
Glutathione Peroxidase
GSK-3
Proteasome
Integrin
Dehydrogenase
YAP
Antioxidant
LTR
Na+/Ca2+ Exchanger
Serine Protease
Serine/threonin kinase
Caspase
Annexin A
Adiponectin receptor
Anion Exchanger
N-Acetylglucosaminyltransferase
Rho
Cysteine Protease
E1/E2/E3 Enzyme
PAFR
CDK
P2X Receptor
ROS
BCL
HCN Channel
HSV
Vasopressin Receptor
Aurora Kinase
cAMP
ATP Citrate Lyase
BCRP
SARS-CoV
Sirtuin
PDGFR
PAK
Hedgehog/Smoothened
FAAH
Epoxide Hydrolase
IGF-1R
Indoleamine 2,3-Dioxygenase (IDO)
mTOR
SGLT
Lipid
MAPK
OAT
Antiviral
IκB/IKK
GST
MEK
AhR
ASK
Reverse Transcriptase
Retinoid Receptor
CRISPR/Cas9
GPR
Phospholipase
c-RET
Gap Junction Protein
Neurokinin receptor
DNA Methyltransferase
NADPH-oxidase
Ras
Sigma receptor
HIF/HIF Prolyl-Hydroxylase
p53
HER

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