Anti-Hypertension Compound Library

Catalog No. L7110

Library Compound List Excel SDF

Hypertension (hypertension) is a clinical syndrome characterized by increased arterial blood pressure (systolic and/or diastolic) in the body circulation (systolic blood pressure ≥ 140 mm Hg and diastolic blood pressure ≥ 90 mm Hg), often accompanied by clinical syndromes including metabolic disorders of fat and glucose, functional or organic changes in the heart, brain, kidney, and retina. Hypertension is the most common chronic disease and is the most important risk factor for cardiovascular and cerebrovascular diseases. The results of several studies suggest that intervention of blood pressure, early prevention and treatment of hypertension can help reduce the risk of cardiovascular disease.

Drugs for the treatment of hypertension are divided into five main categories.

1. Angiotensin-converting enzyme inhibitor (ACEI): Their mechanism of action is mainly based on the inhibition of the angiotensin-converting enzyme so that the secretion of angiotensin, aldosterone and vasopressin is reduced. The reduction of these substances can cause a series of effects such as vasodilation, reduction of vascular peripheral resistance, increase of water and sodium discharge, and reduction of blood volume, thus bringing down blood pressure. In addition, ACEI drugs have the effect of blocking the hydrolysis of bradykinin, which can increase the concentration of bradykinin as well as the secretion of prostaglandins that effectively dilate blood vessels and lower blood pressure. Examples include Captopril, Enalapril, Fosinopril, Lisinopril, etc.

2. Angiotensin receptor antagonist (ARB): Their mechanism of action is similar to that of ACEI, which inhibits the secretion of angiotensin and lowers blood pressure. ARB drugs are widely favored because unlike ACEI drugs, they do not lead to hacking cough. Examples of ARB drugs include Valsartan, Losartan, Telmisartan, Irbesartan, etc.

3. β-receptor antagonist: Their Anti-hypertension mechanism is mainly based on the reduction of cardiac blood output, where the body produces an adaptive response, causing a reduction in peripheral vascular resistance and blood pressure. At the same time, the β-receptors are blocked, sympathetic nerve fiber nerve conduction is reduced, and the release of norepinephrine is decreased, thus the blood pressure is further decreased. Examples of β-receptor antagonist drugs include Atenolol, Metoprolol, Bisoprolol, Carvedilol, etc.

4. Calcium Chanel Blocker (CCB): They mainly prevent the transfer of calcium ions from extracellular to intracellular, so that the intracellular calcium ion concentration is reduced, thus reducing the contractility of cardiomyocytes, and also reducing the excitability of the sinoatrial node and the conduction of the atrioventricular node, achieving a decrease in blood pressure. In addition, CCB drugs have a powerful effect of dilating small arterial vessels. Examples of CCB drugs include nifedipine, amlodipine, etc.

5.diuretics: these drugs affect the kidney mainly by diuretic sodium excretion that reduces the extracellular volume and decreases peripheral vascular resistance. Therefore, the Anti-hypertension effect of this class of drugs is smooth and slow, with a relatively long duration. According to drug classification, there are thiazide diuretics such as hydrochlorothiazide, tab diuretics such as furosemide, and potassium-protective diuretics such as spironolactone.

TargetMol Anti-hypertension Compound Library is a collection of 524 hypertension-related small molecules, including compounds with Anti-hypertension effects and compounds that act on hypertension-related targets, that support your research or related drug screening.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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Product Description

719 hypertension-related small molecules for high-throughput and high-content screening.
Targets include ACE, calcium channel, β-adrenergic receptor, HMG-CoA Reductase, etc.
Detailed instructions, compound structure, target information, activity description, etc.
NMR and HPLC analytical techniques to ensure high product purity and quality.
All compounds are available in stock.

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Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Adrenergic Receptor (163)

Calcium Channel (104)

Dopamine Receptor (67)

RAAS (58)

PPAR (56)

5-HT Receptor (43)

AMPK (38)

P450 (25)

Potassium Channel (24)

AChR (21)

HMG-CoA Reductase (17)

Epigenetic Reader Domain (13)

Histamine Receptor (13)

BACE (12)

COX (10)

Carbonic Anhydrase (10)

Histone Acetyltransferase (10)

Endothelin Receptor (9)

NF-κB (9)

Sodium Channel (9)

Norepinephrine (8)

Prostaglandin Receptor (8)

Acetyl-CoA Carboxylase (7)

PDE (7)

Endogenous Metabolite (6)

CaMK (5)

Glucocorticoid Receptor (5)

MRP (5)

ATPase (5)

ROCK (5)

VEGFR (5)

GABA Receptor (4)

Apoptosis (4)

PKC (4)

LDL (3)

MAO (3)

IL Receptor (3)

Hydroxylase (3)

Antifection (3)

Thrombin (3)

Opioid Receptor (3)

TRP/TRPV Channel (3)

Autophagy (3)

TNF (3)

NMDAR (2)

Serine Protease (2)

Src (2)

ABC (2)

STAT (2)

Lipoxygenase (2)

MMP (2)

PI3K (2)

Tyrosinase (2)

P-gp (2)

NADPH (2)

Na-K-Cl cotransporter (2)

Neprilysin (2)

SIK (2)

Nrf2 (2)

Integrin (2)

Wnt/beta-catenin (2)

Bradykinin Receptor (2)

ERK (2)

GluR (2)

Androgen Receptor (2)

Akt (2)

Beta Amyloid (2)

Fatty Acid Synthase (2)

DNA/RNA Synthesis (2)

PKA (1)

cAMP (1)

Rho (1)

BCRP (1)

BCL (1)

ATP Citrate Lyase (1)

Phospholipase (1)

RAR/RXR (1)

Caspase (1)

Reductase (1)

Retinoid Receptor (1)

Antiviral (1)

ASK (1)

TGF-beta/Smad (1)

Vitamin (1)

Adenosine Receptor (1)

Vasopressin Receptor (1)

Adiponectin receptor (1)

AhR (1)

transporter (1)

Anion Exchanger (1)

ROS (1)

Annexin A (1)

Antibacterial (1)

Sirtuin (1)

Antioxidant (1)

SGLT (1)

Serine/threonin kinase (1)

Chloride channel (1)

PDGFR (1)

Histone Acetylation (1)

PAFR (1)

JNK (1)

Mitophagy (1)

MEK (1)

LTR (1)

GPR (1)

Lipid (1)

GST (1)

IκB/IKK (1)

Monoamine Transporter (1)

Guanylate cyclase (1)

HCN Channel (1)

IGF-1R (1)

HDAC (1)

HIF (1)

HIV Protease (1)

Gap Junction Protein (1)

MPO (1)

p53 (1)

EGFR (1)

Histone Methyltransferase (1)

P2 Receptor (1)

Cysteine Protease (1)

Dehydrogenase (1)

NOS (1)

E1/E2/E3 Enzyme (1)

NKCC (1)

Gamma-secretase (1)

Epoxide Hydrolase (1)

Neurokinin receptor (1)

FAAH (1)

NADPH-oxidase (1)

N-Acetylglucosaminyltransferase (1)

mTOR (1)

c-RET (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty