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NDM-1-IN-11
Catalog No. T214152 Copy Product Info
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NDM-1-IN-11 is a potent covalent inhibitor of NDM-1 with an IC50 of 1.12 μM, acting by forming a Se-S bond with the enzyme. In both in vivo and in vitro models, NDM-1-IN-11, when combined with Meropenem, effectively inhibits the growth of NDM-1-producing E. coli. This compound is suitable for research addressing bacterial resistance caused by NDM-1.
NDM-1-IN-11
Copy Product Info🥰Excellent
Catalog No. T214152
NDM-1-IN-11 is a potent covalent inhibitor of NDM-1 with an IC50 of 1.12 μM, acting by forming a Se-S bond with the enzyme. In both in vivo and in vitro models, NDM-1-IN-11, when combined with Meropenem, effectively inhibits the growth of NDM-1-producing E. coli. This compound is suitable for research addressing bacterial resistance caused by NDM-1.
NDM-1-IN-11
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NDM-1-IN-11 is a potent covalent inhibitor of NDM-1 with an IC50 of 1.12 μM, acting by forming a Se-S bond with the enzyme. In both in vivo and in vitro models, NDM-1-IN-11, when combined with Meropenem, effectively inhibits the growth of NDM-1-producing E. coli. This compound is suitable for research addressing bacterial resistance caused by NDM-1. |
| Targets&IC50 | NDM1:1.12 μM |
| In vitro | NDM-1-IN-11 (compound 27k) demonstrates strong synergy with Meropenem, showing a minimum inhibitory concentration (MIC) of ≤32 µg/mL against Carbapenem-resistant Enterobacteriaceae (CRE) isolates producing NDM-1. Additionally, NDM-1-IN-11 at concentrations of 0-64 μg/mL over 0-8 hours restores the activity of Meropenem against NDM-1-producing Carbapenem-resistant Escherichia coli (strains ZJ487 and TG-1). The compound does not exhibit significant cytotoxicity in HEK-293T and RAW264.7 cells at 0-64 μg/mL for 6 hours. |
| In vivo | Administering NDM-1-IN-11 (10 mg/kg, subcutaneously, every 12 hours for a total of three doses) in combination with Meropenem effectively reduces the bacterial load of E. coli ZJ487 in mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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