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GSK3787

Name: GSK3787
Brand: TargetMol
SKU: T1941
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1941Cas No. 188591-46-0

GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).

GSK3787

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Purity: 99.56%

Catalog No. T1941Cas No. 188591-46-0

GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	In Stock	In Stock
10 mg	$79	In Stock	In Stock
25 mg	$183	In Stock	In Stock
50 mg	$325	In Stock	In Stock
100 mg	$548	In Stock	In Stock
500 mg	$1,170	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.56%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).
Targets&IC50	PPARδ:6.6(pIC50)
In vivo	Pparβ/δ-null mice are administered GSK3787 (10 mg/kg) by oral gavage 3 hours before euthanasia.

Chemical Properties

Molecular Weight	392.78
Formula	C₁₅H₁₂ClF₃N₂O₃S
Cas No.	188591-46-0
Smiles	FC(F)(F)c1ccc(nc1)S(=O)(=O)CCNC(=O)c1ccc(Cl)cc1
Relative Density.	1.448 g/cm3 at 20℃

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (318.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5460 mL	12.7298 mL	25.4595 mL	127.2977 mL
5 mM	0.5092 mL	2.5460 mL	5.0919 mL	25.4595 mL
10 mM	0.2546 mL	1.2730 mL	2.5460 mL	12.7298 mL
20 mM	0.1273 mL	0.6365 mL	1.2730 mL	6.3649 mL
50 mM	0.0509 mL	0.2546 mL	0.5092 mL	2.5460 mL
100 mM	0.0255 mL	0.1273 mL	0.2546 mL	1.2730 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc