keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors. and hematologic tumors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 228.00 | |
5 mg | In stock | $ 679.00 | |
10 mg | In stock | $ 987.00 | |
25 mg | In stock | $ 1,670.00 | |
50 mg | In stock | $ 2,180.00 | |
100 mg | In stock | $ 2,800.00 |
Description | Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors. and hematologic tumors. |
Targets&IC50 | PLK1:3 nM, PLK2:149 nM, PLK3:393 nM |
In vitro | In KYSE-410 cells, Plogosertib (0, 0.07, 0.15, 0.3, 0.6, 1.25 μM; 72 hours) inhibits cell proliferation in a concentration-dependent manner[2]. |
In vivo | In the HL60 promyelocytic leukemia xenograft model, Plogosertib (40, 54, 67 mg/kg, qd 5/2/5; oral administration) inhibited tumor growth (>87%) without significant loss in body weight[2]. |
Synonyms | CYC140 |
Molecular Weight | 616.797 |
Formula | C34H48N8O3 |
CAS No. | 1137212-79-3 |
keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Plogosertib 1137212-79-3 Cell Cycle/Checkpoint PLK AC010220.2HCl AC-010220 CYC-140 CYC 140 AC 010220 AC-220 AC010220 CYC140 AC 220 Quizartinib dihydrochloride Quizartinib HCl Quizartinib inhibitor inhibit