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Desisobutyryl-ciclesonide

Name: Desisobutyryl-ciclesonide
Brand: TargetMol
SKU: T13646
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13646Cas No. 161115-59-9

Alias Ciclesonide active principle, CIC-AP

Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity.

Desisobutyryl-ciclesonide

🥰Excellent

Catalog No. T13646Alias Ciclesonide active principle, CIC-APCas No. 161115-59-9

Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$68	-	In Stock

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Product Introduction

Bioactivity

Description	Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity.
In vitro	Desisobutyryl-ciclesonide showed approximately 120-fold higher binding affinity for the glucocorticoid receptor compared to ciclesonide, and about 12-fold higher than dexamethasone. [1] In Peripheral blood mononuclear cells from atopic asthmatic children sensitized to Phleum pratense (PhlP5), Desisobutyryl-ciclesonide at as low as 0.003 μM already reduced PhlP5-specific proliferation, with complete inhibition at 0.03 μM (vs. 3 μM for ciclesonide). In cultures stimulated with PhlP5, 3 μM Desisobutyryl-ciclesonide significantly reduced the proliferation of PhlP5-specific T-cell blasts and decreased the proportion of interleukin-4 (IL-4) producing cells, indicating suppression of Th2 inflammatory response. [2]
In vivo	In a bleomycin-induced bronchopulmonary dysplasia (BPD) neonatal rat model, systemic administration of Desisobutyryl-ciclesonide significantly reduced inflammation with less impact on weight gain, serum IGF-1, and glucose levels compared to dexamethasone, suggesting a safer profile for developmental outcomes. [3]
Synonyms	Ciclesonide active principle, CIC-AP

Chemical Properties

Molecular Weight	470.6
Formula	C₂₈H₃₈O₆
Cas No.	161115-59-9
Smiles	C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(O[C@H](O2)[C@H]4CCCCC4)[H])([C@]5([C@]([C@@H](O)C3)([C@]6(C)C(CC5)=CC(=O)C=C6)[H])[H])[H]
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (170 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1249 mL	10.6247 mL	21.2495 mL	106.2473 mL
5 mM	0.4250 mL	2.1249 mL	4.2499 mL	21.2495 mL
10 mM	0.2125 mL	1.0625 mL	2.1249 mL	10.6247 mL
20 mM	0.1062 mL	0.5312 mL	1.0625 mL	5.3124 mL
50 mM	0.0425 mL	0.2125 mL	0.4250 mL	2.1249 mL
100 mM	0.0212 mL	0.1062 mL	0.2125 mL	1.0625 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc