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Desisobutyryl-ciclesonide
🥰Excellent
Catalog No. T13646Cas No. 161115-59-9
Alias Ciclesonide active principle, CIC-AP
Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity.
Desisobutyryl-ciclesonide
🥰Excellent
Catalog No. T13646Alias Ciclesonide active principle, CIC-APCas No. 161115-59-9
Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $68 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity. |
| In vitro | Desisobutyryl-ciclesonide showed approximately 120-fold higher binding affinity for the glucocorticoid receptor compared to ciclesonide, and about 12-fold higher than dexamethasone. [1] In Peripheral blood mononuclear cells from atopic asthmatic children sensitized to Phleum pratense (PhlP5), Desisobutyryl-ciclesonide at as low as 0.003 μM already reduced PhlP5-specific proliferation, with complete inhibition at 0.03 μM (vs. 3 μM for ciclesonide). In cultures stimulated with PhlP5, 3 μM Desisobutyryl-ciclesonide significantly reduced the proliferation of PhlP5-specific T-cell blasts and decreased the proportion of interleukin-4 (IL-4) producing cells, indicating suppression of Th2 inflammatory response. [2] |
| In vivo | In a bleomycin-induced bronchopulmonary dysplasia (BPD) neonatal rat model, systemic administration of Desisobutyryl-ciclesonide significantly reduced inflammation with less impact on weight gain, serum IGF-1, and glucose levels compared to dexamethasone, suggesting a safer profile for developmental outcomes. [3] |
| Alias | Ciclesonide active principle, CIC-AP |
| Molecular Weight | 470.6 |
| Formula | C28H38O6 |
| Cas No. | 161115-59-9 |
| Smiles | C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(O[C@H](O2)[C@H]4CCCCC4)[H])([C@]5([C@]([C@@H](O)C3)([C@]6(C)C(CC5)=CC(=O)C=C6)[H])[H])[H] |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (170 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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