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Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity.
Pack Size | Price | Availability | Quantity |
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2 mg | $68 | In Stock |
Description | Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity. |
In vitro | Desisobutyryl-ciclesonide showed approximately 120-fold higher binding affinity for the glucocorticoid receptor compared to ciclesonide, and about 12-fold higher than dexamethasone. [1] In Peripheral blood mononuclear cells from atopic asthmatic children sensitized to Phleum pratense (PhlP5), Desisobutyryl-ciclesonide at as low as 0.003 μM already reduced PhlP5-specific proliferation, with complete inhibition at 0.03 μM (vs. 3 μM for ciclesonide). In cultures stimulated with PhlP5, 3 μM Desisobutyryl-ciclesonide significantly reduced the proliferation of PhlP5-specific T-cell blasts and decreased the proportion of interleukin-4 (IL-4) producing cells, indicating suppression of Th2 inflammatory response. [2] |
In vivo | In a bleomycin-induced bronchopulmonary dysplasia (BPD) neonatal rat model, systemic administration of Desisobutyryl-ciclesonide significantly reduced inflammation with less impact on weight gain, serum IGF-1, and glucose levels compared to dexamethasone, suggesting a safer profile for developmental outcomes. [3] |
Alias | Ciclesonide active principle, CIC-AP |
Molecular Weight | 470.6 |
Formula | C28H38O6 |
Cas No. | 161115-59-9 |
Smiles | C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(O[C@H](O2)[C@H]4CCCCC4)[H])([C@]5([C@]([C@@H](O)C3)([C@]6(C)C(CC5)=CC(=O)C=C6)[H])[H])[H] |
Relative Density. | 1.31g/cm3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (170 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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