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Desisobutyryl-ciclesonide

Name: Desisobutyryl-ciclesonide
Brand: TargetMol
SKU: T13646
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13646Cas No. 161115-59-9

Alias Ciclesonide active principle, CIC-AP

Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity.

Desisobutyryl-ciclesonide

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Catalog No. T13646Alias Ciclesonide active principle, CIC-APCas No. 161115-59-9

Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$68	-	In Stock

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Desisobutyryl-ciclesonide (CIC-AP) is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor.Ciclesonide is a glucocorticoid with anti-inflammatory activity.
In vitro	Desisobutyryl-ciclesonide showed approximately 120-fold higher binding affinity for the glucocorticoid receptor compared to ciclesonide, and about 12-fold higher than dexamethasone. [1] In Peripheral blood mononuclear cells from atopic asthmatic children sensitized to Phleum pratense (PhlP5), Desisobutyryl-ciclesonide at as low as 0.003 μM already reduced PhlP5-specific proliferation, with complete inhibition at 0.03 μM (vs. 3 μM for ciclesonide). In cultures stimulated with PhlP5, 3 μM Desisobutyryl-ciclesonide significantly reduced the proliferation of PhlP5-specific T-cell blasts and decreased the proportion of interleukin-4 (IL-4) producing cells, indicating suppression of Th2 inflammatory response. [2]
In vivo	In a bleomycin-induced bronchopulmonary dysplasia (BPD) neonatal rat model, systemic administration of Desisobutyryl-ciclesonide significantly reduced inflammation with less impact on weight gain, serum IGF-1, and glucose levels compared to dexamethasone, suggesting a safer profile for developmental outcomes. [3]
Synonyms	Ciclesonide active principle, CIC-AP

Chemical Properties

Molecular Weight	470.6
Formula	C₂₈H₃₈O₆
Cas No.	161115-59-9
Smiles	C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(O[C@H](O2)[C@H]4CCCCC4)[H])([C@]5([C@]([C@@H](O)C3)([C@]6(C)C(CC5)=CC(=O)C=C6)[H])[H])[H]
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (170 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1249 mL	10.6247 mL	21.2495 mL	106.2473 mL
5 mM	0.4250 mL	2.1249 mL	4.2499 mL	21.2495 mL
10 mM	0.2125 mL	1.0625 mL	2.1249 mL	10.6247 mL
20 mM	0.1062 mL	0.5312 mL	1.0625 mL	5.3124 mL
50 mM	0.0425 mL	0.2125 mL	0.4250 mL	2.1249 mL
100 mM	0.0212 mL	0.1062 mL	0.2125 mL	1.0625 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc