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VU-29

Name: VU-29
Brand: TargetMol
SKU: T23515
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23515Cas No. 890764-36-0

Alias VU 29

VU-29 is a positive allosteric mGlu5 receptor modulator with an EC50 of 9 nM and a Ki of 244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes [EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM].

VU-29

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Purity: 99.63%

Catalog No. T23515Alias VU 29Cas No. 890764-36-0

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$173	In Stock	In Stock
50 mg	$287	In Stock	In Stock
100 mg	$413	In Stock	In Stock
200 mg	$589	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

VU-29 AI Summary

VU-29 exhibits multiple bioactivities, showing significant interaction with mGluR5 and antiviral properties. It has a Ki of 250.0 nM in displacing [3H]methoxyPEPy from rat mGluR5 expressed in HEK293 cells and an EC50 of 10.7 nM in potentiating glutamate-induced calcium flux in rat astrocytes. In terms of antiviral activity, VU-29 inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells by 4.01% at 10 µM concentration after 48 hours, as determined by high content imaging, and shows an inhibition rate of 0.65% in VERO-6 cells under similar conditions. The compound also inhibits the SARS-CoV-2 3CL-Pro protease by approximately 16.02% at 20 µM concentration, determined by the FRET response with a peptide substrate. Furthermore, in an enzymatic assay of human HDAC6, VU-29 demonstrates 23.02% inhibition with a commercial peptide substrate and 0.19% inhibition with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	VU-29 is a positive allosteric mGlu5 receptor modulator with an EC50 of 9 nM and a Ki of 244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes [EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM].
Targets&IC50	mGluR5 (rat):224 nM (Ki), mGluR5 (rat):9 nM (EC50), mGluR2 (rat):1.5 μM (EC50), mGluR4 (human):154 nM (EC50), mGluR1 (rat):557 nM (EC50)
Synonyms	VU 29

Chemical Properties

Molecular Weight	384.39
Formula	C₂₂H₁₆N₄O₃
Cas No.	890764-36-0
Smiles	N(C(=O)C1=CC=C(N(=O)=O)C=C1)C=2N(N=C(C2)C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	1.30 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (65.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6015 mL	13.0076 mL	26.0152 mL	130.0762 mL
5 mM	0.5203 mL	2.6015 mL	5.2030 mL	26.0152 mL
10 mM	0.2602 mL	1.3008 mL	2.6015 mL	13.0076 mL
20 mM	0.1301 mL	0.6504 mL	1.3008 mL	6.5038 mL
50 mM	0.0520 mL	0.2602 mL	0.5203 mL	2.6015 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc