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VU-29

Name: VU-29
Brand: TargetMol
SKU: T23515
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T23515Cas No. 890764-36-0

Alias VU 29

VU-29 is a positive allosteric mGlu5 receptor modulator with an EC50 of 9 nM and a Ki of 244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes [EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM].

VU-29

🥰Excellent

Purity: 99.63%

Catalog No. T23515Alias VU 29Cas No. 890764-36-0

Pack Size	Price	Availability
2 mg	$29	In Stock
5 mg	$48	In Stock
10 mg	$83	In Stock
25 mg	$173	In Stock
50 mg	$287	In Stock
100 mg	$413	In Stock
200 mg	$589	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Batch Information

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Purity:99.63%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	VU-29 is a positive allosteric mGlu5 receptor modulator with an EC50 of 9 nM and a Ki of 244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes [EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM].
Targets&IC50	mGluR4 (human):154 nM (EC50), mGluR1 (rat):557 nM (EC50), mGluR2 (rat):1.5 μM (EC50), mGluR5 (rat):224 nM (Ki), mGluR5 (rat):9 nM (EC50)
Synonyms	VU 29

Chemical Properties

Molecular Weight	384.39
Formula	C₂₂H₁₆N₄O₃
Cas No.	890764-36-0
Smiles	N(C(=O)C1=CC=C(N(=O)=O)C=C1)C=2N(N=C(C2)C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	1.30 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (65.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6015 mL	13.0076 mL	26.0152 mL	130.0762 mL
5 mM	0.5203 mL	2.6015 mL	5.2030 mL	26.0152 mL
10 mM	0.2602 mL	1.3008 mL	2.6015 mL	13.0076 mL
20 mM	0.1301 mL	0.6504 mL	1.3008 mL	6.5038 mL
50 mM	0.0520 mL	0.2602 mL	0.5203 mL	2.6015 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc