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Skp2 inhibitor 2
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Catalog No. T78194 Copy Product Info
Purity: 99.92%
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Skp2 inhibitor 2 (14f) is a small-molecule inhibitor of the F-box protein S-phase kinase-associated protein 2 (Skp2), exhibiting an IC50 value of 10.2 μM against the Skp2-Cks1 complex. Skp2 inhibitor 2 (14f) targets Skp2, a component of cullin-RING ligases responsible for substrate recruitment and ubiquitination during both proteolytic and non-proteolytic cellular processes. The biochemical activity of Skp2 inhibitor 2 (14f) supports the application of Skp2 inhibitor 2 (14f) in research investigating ubiquitin-mediated signaling pathways, cell-cycle regulation, protein turnover mechanisms, and cancer-associated molecular networks.
Cas No. 2760612-77-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $253 | - | In Stock | |
| 5 mg | $619 | - | In Stock | |
| 10 mg | $993 | - | In Stock | |
| 25 mg | $1,990 | - | In Stock | |
| 50 mg | $2,680 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $683 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.92%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Skp2 inhibitor 2 (14f) is a small-molecule inhibitor of the F-box protein S-phase kinase-associated protein 2 (Skp2), exhibiting an IC50 value of 10.2 μM against the Skp2-Cks1 complex. Skp2 inhibitor 2 (14f) targets Skp2, a component of cullin-RING ligases responsible for substrate recruitment and ubiquitination during both proteolytic and non-proteolytic cellular processes. The biochemical activity of Skp2 inhibitor 2 (14f) supports the application of Skp2 inhibitor 2 (14f) in research investigating ubiquitin-mediated signaling pathways, cell-cycle regulation, protein turnover mechanisms, and cancer-associated molecular networks. |
| Molecular Weight | 428.57 |
| Formula | C27H32N4O |
| Cas No. | 2760612-77-7 |
| Smiles | O=C(NCC1CCN(C2=NC(C3=CC=CC=C3)=C(N=C2)C=4C=CC=CC4)CC1)C(C)(C)C |
| Storage | Keep away from moisture,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9.6 mg/mL (22.4 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Skp2 inhibitor 2 chemical structure | Skp2 inhibitor 2 formula | Skp2 inhibitor 2 molecular weight
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