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Anti-SIGIRR Antibody-PE (6K128)
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Catalog No. TMAY-02261P
Alias TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Anti-SIGIRR Antibody-PE (6K128) is a PE-conjugated Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody-PE (6K128) can be used in FCM.
Anti-SIGIRR Antibody-PE (6K128)
Anti-SIGIRR Antibody-PE (6K128)
😃Good
Catalog No. TMAY-02261PAlias TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Anti-SIGIRR Antibody-PE (6K128) is a PE-conjugated Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody-PE (6K128) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 T | $128 | 7-10 days | |
| 100 T | $257 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: FCM Reactivity: Human |
| Alias | TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| Ig Type | Rabbit IgG |
| Clone | 6K128 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human SIGIRR expression on SW480 cells. Cells were stained with PE-conjugated anti-Human SIGIRR. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human SIGIRR / TIR8 (rh SIGIRR / TIR8; TMPY-01894; Q6IA17-1; Met1-His118) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge. |
| Conjucates | PE |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Protein: Human SIGIRR / TIR8 protein (TMPY-01894) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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