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Anti-SMC1A Antibody (7H408)

😃Good
Catalog No. TMAC-03804
Alias Structural maintenance of chromosomes protein 1A, SMC1L1, SMC-1-alpha, SMC-1A, SMC1, SMC protein 1A, Sb1.8, SB1.8, KIAA0178, DXS423E

Anti-SMC1A Antibody (7H408) is a Rabbit antibody targeting SMC1A. Anti-SMC1A Antibody (7H408) can be used in WB,ICC/IF,IHC.

Anti-SMC1A Antibody (7H408)

Anti-SMC1A Antibody (7H408)

😃Good
Catalog No. TMAC-03804Alias Structural maintenance of chromosomes protein 1A, SMC1L1, SMC-1-alpha, SMC-1A, SMC1, SMC protein 1A, Sb1.8, SB1.8, KIAA0178, DXS423E
Anti-SMC1A Antibody (7H408) is a Rabbit antibody targeting SMC1A. Anti-SMC1A Antibody (7H408) can be used in WB,ICC/IF,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2987-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-SMC1A Antibody (7H408) is a Rabbit antibody targeting SMC1A. Anti-SMC1A Antibody (7H408) can be used in WB,ICC/IF,IHC.
SynonymsStructural maintenance of chromosomes protein 1A, SMC1L1, SMC-1-alpha, SMC-1A, SMC1, SMC protein 1A, Sb1.8, SB1.8, KIAA0178, DXS423E
Ig Type
IgG
Clone
7H408
Reactivity
Human,Mouse,Rat
Verified Activity
1. Western blot analysis of SMC1 on different lysates using anti-SMC1 antibody at 1/1,000 dilution. Positive control: Lane 1: NIH/3T3, Lane 2: Hela.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-SMC1 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-SMC1 antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-SMC1 antibody. Counter stained with hematoxylin.
5. ICC staining SMC1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. ICC staining SMC1 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
7. ICC staining SMC1 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Recommended Dose
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundThe SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. SMC1α (structural maintenance of chromosomes protein 1A), also known as SMC1, SMCB, CDLS2, SB1.8, SMC1L1 or DXS423E, is a 1,233 amino acid nuclear protein that is involved in chromosome cohesion during the cell cycle. SMC1α interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role in DNA repair. SMC1α is a component of the cohesion complex, which is required for the cohesion of sister chromatids after DNA replication. Mutations in the gene encoding SMC1α may be the cause of Cornelia de Lange syndrome (CdLS), which is a clinically heterogeneous developmental disorder characterized by facial dysmorphia, upper limb malformations, growth and cognitive retardation.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 143 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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