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ABT 102

Name: ABT 102
Brand: TargetMol
SKU: T29522
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29522Cas No. 808756-71-0

Alias CHEMBL398338, ABT-102, ABT102

ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.

ABT 102

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Purity: 99.86%

Catalog No. T29522Alias CHEMBL398338, ABT-102, ABT102Cas No. 808756-71-0

ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$262	In Stock	In Stock
10 mg	$388	In Stock	In Stock
25 mg	$592	In Stock	In Stock
50 mg	$828	In Stock	In Stock
100 mg	$1,110	In Stock	In Stock
200 mg	$1,480	-	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

ee:99.58%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS CSFC

Product Introduction

ABT 102 AI Summary

ABT 102 is a potent antagonist of the human TRPV1 receptor, exhibiting an IC50 of 4.0 nM for capsaicin-induced calcium flux and 0.7 nM for pH 5.5-induced activation. It also shows inhibitory activity against N-arachidonoyl-dopamine with an IC50 of 3.0 nM. The compound displays high permeability across human Caco-2 cells (Papp > 18.0 x 10^-6 cm/s) and demonstrates strong plasma protein binding (PPB 99.78%). In rats, ABT 102 has a half-life of 1.7 hours, a volume of distribution beta of 2.8 L/kg, and plasma clearance of 18.33 mL/min/kg when administered intravenously at 10 μmol/kg in PEG400. It exhibits a Cmax of 717.46 nM and an oral bioavailability of 70.0% under similar dosing conditions. Additionally, the compound decreases carrageenan-induced thermal hyperalgesia in Sprague-Dawley rats with an ED50 of 20.0 μmol/kg and shows a brain-to-plasma ratio of 0.32. The variable intrinsic clearance rates in human liver microsomes (8.32 mL/min/g) compared to rat (20.42 μL/min/(10^6 cells)) and its low intrinsic clearance in human assays suggest metabolic differences. ABT 102 demonstrates mixed effects on cell viability across different cell lines and induces hyperthermia in rats, increasing body temperature by 0.8°C. It also has varying oral bioavailability in dogs and monkeys depending on the administered dose and vehicle..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.
Synonyms	CHEMBL398338, ABT-102, ABT102

Chemical Properties

Molecular Weight	348.44
Formula	C₂₁H₂₄N₄O
Cas No.	808756-71-0
Smiles	N(C(NC1=C2C(NN=C2)=CC=C1)=O)[C@H]3C=4C(=CC(C(C)(C)C)=CC4)CC3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (129.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8699 mL	14.3497 mL	28.6993 mL	143.4967 mL
5 mM	0.5740 mL	2.8699 mL	5.7399 mL	28.6993 mL
10 mM	0.2870 mL	1.4350 mL	2.8699 mL	14.3497 mL
20 mM	0.1435 mL	0.7175 mL	1.4350 mL	7.1748 mL
50 mM	0.0574 mL	0.2870 mL	0.5740 mL	2.8699 mL
100 mM	0.0287 mL	0.1435 mL	0.2870 mL	1.4350 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc