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Anti-Caspase-14 Antibody (5O976)
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Catalog No. TMAY-02110
Alias caspase 14, apoptosis-related cysteine peptidase, ARCI12
Anti-Caspase-14 Antibody (5O976) is a Mouse antibody targeting Caspase-14. Anti-Caspase-14 Antibody (5O976) can be used in IHC-P.
Anti-Caspase-14 Antibody (5O976)
Anti-Caspase-14 Antibody (5O976)
😃Good
Catalog No. TMAY-02110Alias caspase 14, apoptosis-related cysteine peptidase, ARCI12
Anti-Caspase-14 Antibody (5O976) is a Mouse antibody targeting Caspase-14. Anti-Caspase-14 Antibody (5O976) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-Caspase-14 Antibody (5O976) is a Mouse antibody targeting Caspase-14. Anti-Caspase-14 Antibody (5O976) can be used in IHC-P. |
| Alias | caspase 14, apoptosis-related cysteine peptidase, ARCI12 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5O976 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human CASP14 in human skin with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Caspase-14 / CASP14 (rh Caspase-14 / CASP14; TMPY-01824; NP_036246.1; Ser2-Gln242). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Caspase-14 / CASP14 protein (TMPY-01824) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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