B7-1 Protein, Mouse, Recombinant (hFc)

Name: B7-1 Protein, Mouse, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-02363
Rating: 4.5 (1 reviews)

(Synonyms: TSA1, MIC17, Ly-53, Ly53, CD80 molecule, Cd28l, B71) Copy Product Info

Synonyms: TSA1, MIC17, Ly-53, Ly53, CD80 molecule, Cd28l, B71

Catalog No. TMPY-02363 Copy Product Info

B7-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is Q00609-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$39	7-10 days	7-10 days
10 µg	$59	7-10 days	7-10 days
20 µg	$94	7-10 days	7-10 days
50 µg	$183	7-10 days	7-10 days
100 µg	$353	7-10 days	7-10 days
200 µg	$538	7-10 days	7-10 days
500 µg	$1,120	7-10 days	7-10 days
1 mg	$2,320	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	1. Measured by its binding ability in a functional ELISA. 2. Immobilized human CTLA4 at 10 μg/mL (100 μl/well) can bind mouse CD80-Fc , The EC50 of mouse CD80-Fc is 28 ng/mL.
Description	B7-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is Q00609-1.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q00609-1
Construction	A DNA sequence encoding the mouse CD80 (Q00609-1) extracellular domain (Met 1-Lys 245) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Val 38
Protein Purity	> 90 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	TSA1, MIC17, Ly-53, Ly53, CD80 molecule, Cd28l, B71
Research Background	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

50.7 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.