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Naftopidil hydrochloride

Name: Naftopidil hydrochloride
Brand: TargetMol
SKU: T9220
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9220Cas No. 1164469-60-6

Alias KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-

Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.

Naftopidil hydrochloride

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Purity: 99.5%

Catalog No. T9220Alias KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-Cas No. 1164469-60-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$37	In Stock	In Stock
5 mg	$79	In Stock	In Stock
10 mg	$119	In Stock	In Stock
25 mg	$213	In Stock	In Stock
50 mg	$320	In Stock	In Stock
100 mg	$461	In Stock	In Stock
200 mg	$645	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.5%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.
Targets&IC50	α1B-adrenoceptor:20 nM, α1A-adrenoceptor (human):3.7 nM, α1D-adrenoceptor:1.2 nM
In vitro	Naftopidil hydrochloride reduced the extent of lung fibrosis and SP‐D production in bleomycin‐induced lung fibrosis in mice[1].
In vivo	Naftopidil hydrochloride strongly suppressed cell proliferation of stromal cells, resulting in decreased tumorigenic soluble factor, suggesting that naftopidil might be effective in preventing stromal support of tumor cells[2].
Synonyms	KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-

Chemical Properties

Molecular Weight	428.95
Formula	C₂₄H₂₉ClN₂O₃
Cas No.	1164469-60-6
Smiles	Cl.COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (139.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3313 mL	11.6564 mL	23.3127 mL	116.5637 mL
5 mM	0.4663 mL	2.3313 mL	4.6625 mL	23.3127 mL
10 mM	0.2331 mL	1.1656 mL	2.3313 mL	11.6564 mL
20 mM	0.1166 mL	0.5828 mL	1.1656 mL	5.8282 mL
50 mM	0.0466 mL	0.2331 mL	0.4663 mL	2.3313 mL
100 mM	0.0233 mL	0.1166 mL	0.2331 mL	1.1656 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc