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Naftopidil hydrochloride

Name: Naftopidil hydrochloride
Brand: TargetMol
SKU: T9220
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9220Cas No. 1164469-60-6

Alias KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-

Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.

Naftopidil hydrochloride

🥰Excellent

Purity: 99.5%

Catalog No. T9220Alias KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-Cas No. 1164469-60-6

Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$79	In Stock
10 mg	$119	In Stock
25 mg	$213	In Stock
50 mg	$320	In Stock
100 mg	$461	In Stock
200 mg	$645	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Purity:99.5%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.
Targets&IC50	α1D-adrenoceptor:1.2 nM, α1A-adrenoceptor (human):3.7 nM, α1B-adrenoceptor:20 nM
In vitro	Naftopidil hydrochloride reduced the extent of lung fibrosis and SP‐D production in bleomycin‐induced lung fibrosis in mice[1].
In vivo	Naftopidil hydrochloride strongly suppressed cell proliferation of stromal cells, resulting in decreased tumorigenic soluble factor, suggesting that naftopidil might be effective in preventing stromal support of tumor cells[2].
Synonyms	KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-

Chemical Properties

Molecular Weight	428.95
Formula	C₂₄H₂₉ClN₂O₃
Cas No.	1164469-60-6
Smiles	Cl.COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (139.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3313 mL	11.6564 mL	23.3127 mL	116.5637 mL
5 mM	0.4663 mL	2.3313 mL	4.6625 mL	23.3127 mL
10 mM	0.2331 mL	1.1656 mL	2.3313 mL	11.6564 mL
20 mM	0.1166 mL	0.5828 mL	1.1656 mL	5.8282 mL
50 mM	0.0466 mL	0.2331 mL	0.4663 mL	2.3313 mL
100 mM	0.0233 mL	0.1166 mL	0.2331 mL	1.1656 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc