MAO-B-IN-18 is a potent, selective inhibitor of MAO B with IC50 values of 52 nM for hMAO B and 14 μM for hMAO A. It exhibits cytoprotective effects against hydrogen peroxide-induced damage in neuroblastoma and astrocyte cultures [1].

MAO-A (human):14 μM, MAO-B (human):52 nM

MAO-B-IN-18 (Compound 20; 0.1, 0.5, 1, 5 μM) protects neuroblastoma cells in SH-SY5Y cultures from pro-oxidative damage through a pathway involving moderate ROS scavenging [1]. When co-incubated with hydrogen peroxide (400 μM), MAO-B-IN-18 (5 μM) sustains the viability of DI TNC1 astrocyte cell lines at levels comparable to those of the positive control quercetin at a high dose (75 μM) [1].