Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MAO-B-IN-18 is a potent, selective inhibitor of MAO B, demonstrating IC50 values of 52 nM for hMAO B and 14 μM for hMAO A. It exhibits cytoprotective effects against hydrogen peroxide-induced damage in neuroblastoma and astrocyte cultures [1].
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Description | MAO-B-IN-18 is a potent, selective inhibitor of MAO B, demonstrating IC50 values of 52 nM for hMAO B and 14 μM for hMAO A. It exhibits cytoprotective effects against hydrogen peroxide-induced damage in neuroblastoma and astrocyte cultures [1]. |
Targets&IC50 | hMAO-B:52 nM, hMAO-A:14 μM |
In vitro | MAO-B-IN-18 (Compound 20; 0.1, 0.5, 1, 5 μM) protects neuroblastoma cells in SH-SY5Y cultures from pro-oxidative damage through a pathway involving moderate ROS scavenging [1]. When co-incubated with hydrogen peroxide (400 μM), MAO-B-IN-18 (5 μM) sustains the viability of DI TNC1 astrocyte cell lines at levels comparable to those of the positive control quercetin at a high dose (75 μM) [1]. |
Molecular Weight | 458.47 |
Formula | C25H22N4O5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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MAO-B-IN-18 Neuroscience Monoamine Oxidase inhibitor inhibit