Shopping Cart

Your shopping cart is currently empty

Nrf2-Activator-12G

Name: Nrf2-Activator-12G
Brand: TargetMol
SKU: T24546
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T24546Cas No. 1554271-18-9

Alias Nrf2 Activator-IV, Nrf2 Activator IV

Nrf2-Activator-12G (compd 12g) is a direct activator of Nrf2 that induces robust expression of Nrf2-dependent antioxidant enzymes at both mRNA and protein levels in dopaminergic neuronal cells, thereby enhancing cellular defense against oxidative stress and providing a mechanistic platform for investigating neuroprotection and disease-modifying strategies in Parkinson’s disease research.

Nrf2-Activator-12G

Copy Product Info

😃Good

Purity: 99.92%

Catalog No. T24546Alias Nrf2 Activator-IV, Nrf2 Activator IVCas No. 1554271-18-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$64	-	In Stock
10 mg	$106	-	In Stock
25 mg	$176	-	In Stock
50 mg	$262	-	In Stock
100 mg	$389	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Nrf2-Activator-12G (compd 12g) is a direct activator of Nrf2 that induces robust expression of Nrf2-dependent antioxidant enzymes at both mRNA and protein levels in dopaminergic neuronal cells, thereby enhancing cellular defense against oxidative stress and providing a mechanistic platform for investigating neuroprotection and disease-modifying strategies in Parkinson’s disease research.
In vivo	In mouse models of Parkinson’s disease, such as those induced by MPTP neurotoxicity, Nrf2-Activator-12G mitigate oxidative damage and reduce neuroinflammation [1].
Synonyms	Nrf2 Activator-IV, Nrf2 Activator IV

Chemical Properties

Molecular Weight	308.78
Formula	C₁₅H₁₃ClO₃S
Cas No.	1554271-18-9
Smiles	S(/C=C/C1=C(Cl)C=CC=C1)(=O)(=O)C2=C(OC)C=CC=C2
Relative Density.	1.308 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (259.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2386 mL	16.1928 mL	32.3855 mL	161.9276 mL
5 mM	0.6477 mL	3.2386 mL	6.4771 mL	32.3855 mL
10 mM	0.3239 mL	1.6193 mL	3.2386 mL	16.1928 mL
20 mM	0.1619 mL	0.8096 mL	1.6193 mL	8.0964 mL
50 mM	0.0648 mL	0.3239 mL	0.6477 mL	3.2386 mL
100 mM	0.0324 mL	0.1619 mL	0.3239 mL	1.6193 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc