Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) is a Thalidomide-based synthetic E3 ligase ligand-linker conjugate, comprising of a cereblon ligand and a linker. This compound is employed in the production of PROTACs (proteolysis-targeting chimeras).
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Description | Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) is a Thalidomide-based synthetic E3 ligase ligand-linker conjugate, comprising of a cereblon ligand and a linker. This compound is employed in the production of PROTACs (proteolysis-targeting chimeras). |
In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Synonyms | E3LigaseLigand-LinkerConjugates25, Cereblon Ligand-Linker Conjugates 11, Thalidomide-O-amido-C6-NH2 |
Molecular Weight | 430.45 |
Formula | C21H26N4O6 |
CAS No. | 1950635-13-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Thalidomide-O-amido-C6-NH2 1950635-13-8 Thalidomide O amido C6 NH2 E3LigaseLigand-LinkerConjugates25 Cereblon Ligand-Linker Conjugates 11 ThalidomideOamidoC6NH2 Thalidomide-O-amido-C-6-NH2 inhibitor inhibit