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CRTH2-IN-1
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Catalog No. T10891Cas No. 926661-54-3
Alias Ramatroban analog
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
CRTH2-IN-1
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Catalog No. T10891Alias Ramatroban analogCas No. 926661-54-3
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay. |
| Targets&IC50 | DP1 (human):1 μM, CYP3A4:7 μM, CYP2C9:5 μM, DP2 (human):6 nM |
| In vitro | CRTH2-IN-1 (Ramatroban analog) is a new type of prostaglandin D2 receptor DP2 (CRTH2) antagonist with IC50 of 7 nM in human whole blood eosinophil deformation assay (hESC). It has efficacy in a mouse model of allergic rhinitis. Using 3H-PGD2 and human platelet membrane for human prostaglandin D1 receptor (hDP1) binding. Human thromboxane receptor (hTP) binding was performed using human platelet membrane and 3H-SQ-29,548. HIP / 293 membrane and 3Hiloprost were used for human prostacyclin receptor (hIP) binding. CRTH2-IN-1 inhibits hDP1 binding with IC50 of 1 μM. CRTH2-IN-1 inhibits the combination of hTP and hIP with IC50 greater than 100 μM. CRTH2-IN-1 inhibits human CYP subtypes CYP3A4, CYP 2C9 and CYP2D6 with IC50 of 7, 5 and> 30 μM, respectively. |
| Synonyms | Ramatroban analog |
| Molecular Weight | 416.47 |
| Formula | C21H21FN2O4S |
| Cas No. | 926661-54-3 |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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