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Anti-PKD2L1 Polyclonal Antibody

Catalog No. TMAB-11498 Copy Product Info
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Anti-PKD2L1 Polyclonal Antibody is a Rabbit antibody targeting PKD2L1. Anti-PKD2L1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-PKD2L1 Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-11498

Anti-PKD2L1 Polyclonal Antibody is a Rabbit antibody targeting PKD2L1. Anti-PKD2L1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-PKD2L1 Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2227-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5277-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-PKD2L1 Polyclonal Antibody is a Rabbit antibody targeting PKD2L1. Anti-PKD2L1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Human
Verified Activity
Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (PKD2L1) Polyclonal Antibody, Unconjugated (TMAB-11498) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining.
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCell projection › cilium membrane; Multi-pass membrane protein
Tissue SpecificityExpressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to PubMed:9748274, expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues. According to PubMed:10602361, expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human PKD2L1
Antigen Species
Human
Gene Name
PKD2L1
Gene ID
Protein Name
Polycystic kidney disease 2-like 1 protein
Uniprot ID
Function
Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
Chemical Properties
Molecular WeightTheoretical: 92 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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