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PROTO-1

Name: PROTO-1
Brand: TargetMol
SKU: T16668
Rating: 4.5 (1 reviews)

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Catalog No. T16668Cas No. 312951-85-2

PROTO-1 displays obviously protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).

PROTO-1

😃Good

Catalog No. T16668Cas No. 312951-85-2

PROTO-1 displays obviously protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$198	6-8 weeks	6-8 weeks
5 mg	$347	6-8 weeks	6-8 weeks
25 mg	$1,140	6-8 weeks	6-8 weeks
50 mg	$1,490	6-8 weeks	6-8 weeks
100 mg	$1,990	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$382	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PROTO-1 displays obviously protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).
In vitro	PROTO-1 shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM. Pretreatment with PROTO-1( 1 and 10 μM) causes significant protection of hair cells exposed to 200 μM neomycin compared to neomycin alone. PROTO-1 protection against neomycin is tested at 4 mM neomycin and showed significant striolar [2]

Chemical Properties

Molecular Weight	378.88
Formula	C₁₇H₁₉ClN₄O₂S
Cas No.	312951-85-2
Relative Density.	1.427 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (329.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.71 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6394 mL	13.1968 mL	26.3936 mL	131.9679 mL
5 mM	0.5279 mL	2.6394 mL	5.2787 mL	26.3936 mL
10 mM	0.2639 mL	1.3197 mL	2.6394 mL	13.1968 mL
20 mM	0.1320 mL	0.6598 mL	1.3197 mL	6.5984 mL
50 mM	0.0528 mL	0.2639 mL	0.5279 mL	2.6394 mL
100 mM	0.0264 mL	0.1320 mL	0.2639 mL	1.3197 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PROTO1PROTO 1PROTO-1