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DAO-IN-1

Name: DAO-IN-1
Brand: TargetMol
SKU: T78231
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78231Cas No. 51856-25-8

DAO-IN-1 (compound 10) is a potent DAO (D -amino acid oxidase) inhibitor with an IC50=269 ± 77nM for human DAO that ameliorates schizophrenia by increasing D -serine levels in the brain.

DAO-IN-1

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Purity: 99.84%

Catalog No. T78231Cas No. 51856-25-8

DAO-IN-1 (compound 10) is a potent DAO (D -amino acid oxidase) inhibitor with an IC50=269 ± 77nM for human DAO that ameliorates schizophrenia by increasing D -serine levels in the brain.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$61	In Stock
25 mg	$100	In Stock
50 mg	$147	In Stock
100 mg	$238	In Stock
200 mg	$353	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Purity:99.84%

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COA LCMS HNMR

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Product Introduction

Bioactivity

Description	DAO-IN-1 (compound 10) is a potent DAO (D -amino acid oxidase) inhibitor with an IC50=269 ± 77nM for human DAO that ameliorates schizophrenia by increasing D -serine levels in the brain.
Targets&IC50	DAO (human, CHO cells):269 ± 77 nM
In vitro	DAO-IN-1 exhibited potent inhibitory activity in a CHO cell model overexpressing human DAO (IC₅₀ = 269 ± 77 nM)[1].

Chemical Properties

Molecular Weight	167.19
Formula	C₇H₅NO₂S
Cas No.	51856-25-8
Smiles	O=C(O)C1=CC=2C=CSC2N1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (478.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9812 mL	29.9061 mL	59.8122 mL	299.0609 mL
5 mM	1.1962 mL	5.9812 mL	11.9624 mL	59.8122 mL
10 mM	0.5981 mL	2.9906 mL	5.9812 mL	29.9061 mL
20 mM	0.2991 mL	1.4953 mL	2.9906 mL	14.9530 mL
50 mM	0.1196 mL	0.5981 mL	1.1962 mL	5.9812 mL
100 mM	0.0598 mL	0.2991 mL	0.5981 mL	2.9906 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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