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Ranirestat

Name: Ranirestat
Brand: TargetMol
SKU: T16723
Price: 189 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16723Cas No. 147254-64-6

Alias SX-3030, SX3030, AS-3201, AS3201, AS 3201

Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy.

Ranirestat

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Purity: 99.44%

Catalog No. T16723Alias SX-3030, SX3030, AS-3201, AS3201, AS 3201Cas No. 147254-64-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
2 mg	$68	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$189	In Stock	In Stock
25 mg	Preferential	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$173	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.44%

ee:98.90%

Appearance:Solid

Color:White

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COA CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy.
Targets&IC50	Recombinant humanaldose reductase:0.38 nM （Ki）, Recombinant humanaldose reductase:15 nM, Aldose reductase (rat lens):11 nM
In vitro	Ranirestat concentration-dependently inhibits sorbitol accumulation in rat erythrocytes and sciatic nerves incubated in a high concentration (500 mg/dl) of glucose[1].
In vivo	In approximately 12-week-old male STD-Wistar rats (260-290 g) injected with Streptozotocin (STZ), Ranirestat (0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg; oral administration, once daily, for 3 weeks) dose-dependently decreased the elevated sorbitol and fructose levels in the rat sciatic nerves without affecting blood glucose levels[1].
Synonyms	SX-3030, SX3030, AS-3201, AS3201, AS 3201

Chemical Properties

Molecular Weight	420.19
Formula	C₁₇H₁₁BrFN₃O₄
Cas No.	147254-64-6
Smiles	Fc1cc(Br)ccc1CN1C(=O)c2cccn2[C@@]2(CC(=O)NC2=O)C1=O
Relative Density.	1.83 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (71.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3799 mL	11.8994 mL	23.7988 mL	118.9938 mL
5 mM	0.4760 mL	2.3799 mL	4.7598 mL	23.7988 mL
10 mM	0.2380 mL	1.1899 mL	2.3799 mL	11.8994 mL
20 mM	0.1190 mL	0.5950 mL	1.1899 mL	5.9497 mL
50 mM	0.0476 mL	0.2380 mL	0.4760 mL	2.3799 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc