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3-CPMT

Name: 3-CPMT
Brand: TargetMol
SKU: T22508
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22508Cas No. 14008-79-8

Alias Wy 2149, SL6057, FC-1, Chlortropbenzyl hydrochloride, 3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride

3-CPMT (FC-1) is a dopamine uptake inhibitor and a potent long-acting antihistaminic agent.

3-CPMT

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Purity: 99.03%

Catalog No. T22508Alias Wy 2149, SL6057, FC-1, Chlortropbenzyl hydrochloride, 3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochlorideCas No. 14008-79-8

3-CPMT (FC-1) is a dopamine uptake inhibitor and a potent long-acting antihistaminic agent.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$37	In Stock	In Stock
10 mg	$53	In Stock	In Stock
25 mg	$89	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.03%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

3-CPMT AI Summary

3-CPMT shows a diverse range of bioactivities. It exhibits differential inhibitors of proliferation for various strains of Plasmodium falciparum, with potencies from 1122.0 nM to 8912.5 nM and demonstrates antiviral activities by inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 cells (9.7% inhibition at 10 µM) and VERO-6 cells (1.16% inhibition at 10 µM). Moreover, it inhibits SARS-CoV-2 3CL-Pro protease by 7.177% at 20 µM concentration. 3-CPMT is also effective in inducing the Erasure of Genomic Imprints (potency: 12589.3 nM), enhancing SMN2 splice variant expression (potency: 35481.3 nM), inhibiting Tau fibril formation (potency: 14125.4 nM), and modulating Lamin A splicing (potency: 5623.4 nM). Additionally, it shows activity against Lassa infection with a 8912.5 nM potency. The compound is a counterscreen for APE1 inhibitors, inhibiting endonuclease IV (potency: 10000.0 nM), and inhibits histone lysine methyltransferase G9a (potency: 22.4 nM) and mammalian selenoprotein thioredoxin reductase 1 (TrxR1) (potency: 23.8 nM). Lastly, it inhibits hERG channel activity with a potency of 501.2 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3-CPMT (FC-1) is a dopamine uptake inhibitor and a potent long-acting antihistaminic agent.
Synonyms	Wy 2149, SL6057, FC-1, Chlortropbenzyl hydrochloride, 3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride

Chemical Properties

Molecular Weight	378.33
Formula	C₂₁H₂₅Cl₂NO
Cas No.	14008-79-8
Smiles	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (26.43 mM), Sonication is recommended.

Ethanol: 2 mg/mL (5.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6432 mL	13.2160 mL	26.4320 mL	132.1598 mL
5 mM	0.5286 mL	2.6432 mL	5.2864 mL	26.4320 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2643 mL	1.3216 mL	2.6432 mL	13.2160 mL
20 mM	0.1322 mL	0.6608 mL	1.3216 mL	6.6080 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc