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Ropsacitinib

Name: Ropsacitinib
Brand: TargetMol
SKU: T13237L
Price: 243 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13237LCas No. 2127109-84-4

Alias Tyk2-IN-8, PF-06826647

Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM).

Ropsacitinib

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Purity: 99.87%

Catalog No. T13237LAlias Tyk2-IN-8, PF-06826647Cas No. 2127109-84-4

Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM).

Pack Size	Price	Availability
1 mg	$243	In Stock
2 mg	$365	In Stock
5 mg	$518	In Stock
10 mg	$749	In Stock
25 mg	$1,160	In Stock
50 mg	$1,570	In Stock

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Batch Information

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Purity:99.87%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM).
Targets&IC50	TYK2 JH1:17 nM
In vitro	Ropsacitinib suppresses JAK1 (IC50=74 nM) and JAK2 (IC50=383 nM) [1].
Synonyms	Tyk2-IN-8, PF-06826647

Chemical Properties

Molecular Weight	383.41
Formula	C₂₀H₁₇N₉
Cas No.	2127109-84-4
Smiles	C(C#N)[C@@]1(C[C@H](C#N)C1)N2C=C(C=N2)C=3C=4N(C=C(N3)C=5C=NN(C)C5)N=CC4
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (26.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6082 mL	13.0409 mL	26.0817 mL	130.4087 mL
5 mM	0.5216 mL	2.6082 mL	5.2163 mL	26.0817 mL
10 mM	0.2608 mL	1.3041 mL	2.6082 mL	13.0409 mL
20 mM	0.1304 mL	0.6520 mL	1.3041 mL	6.5204 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc