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4-Hydroxytolbutamide is a sulfonylurea and drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 Tolbutamide (HLS 831) is a sulfonylurea hypoglycemic agent.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | TBD | 35 days | |
5 mg | TBD | 35 days | |
10 mg | TBD | 35 days | |
25 mg | TBD | 35 days |
Description | 4-Hydroxytolbutamide is a sulfonylurea and drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 Tolbutamide (HLS 831) is a sulfonylurea hypoglycemic agent. |
In vitro | 4-Hydroxytolbutamide is the primary metabolite of tolbutamide, formed via CYP2C9 in humans and CYP2C11 in rats. In rat liver microsomes, the hydroxylation of tolbutamide follows typical Michaelis–Menten kinetics, indicating enzyme-mediated metabolism. [1] |
In vivo | In poloxamer 407-induced hyperlipidemic rats, intravenous or oral administration of tolbutamide (10 mg/kg) produced significantly lower AUC values for 4-Hydroxytolbutamide compared to normal rats, indicating reduced metabolic conversion. [2] |
Alias | Hydroxytolbutamide |
Molecular Weight | 286.35 |
Formula | C12H18N2O4S |
Cas No. | 5719-85-7 |
Smiles | O=C(NCCCC)NS(=O)(=O)C1=CC=C(C=C1)CO |
Relative Density. | 1.268 g/cm3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (349.22 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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