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4-Hydroxytolbutamide (Synonyms: Hydroxytolbutamide)

Name: 4-Hydroxytolbutamide
Brand: TargetMol
SKU: T14040
Rating: 4.5 (1 reviews)

Catalog No. T14040 Copy Product Info

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4-Hydroxytolbutamide is a sulfonylurea and drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 Tolbutamide (HLS 831) is a sulfonylurea hypoglycemic agent.

4-Hydroxytolbutamide

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Catalog No. T14040

Synonyms Hydroxytolbutamide

4-Hydroxytolbutamide is a sulfonylurea and drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 Tolbutamide (HLS 831) is a sulfonylurea hypoglycemic agent.

Cas No. 5719-85-7

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Pack Size	Price	USA Stock	Global Stock
1 mg	$142	35 days	35 days
5 mg	$555	35 days	35 days
10 mg	$987	35 days	35 days
25 mg	$2,390	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	4-Hydroxytolbutamide is a sulfonylurea and drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 Tolbutamide (HLS 831) is a sulfonylurea hypoglycemic agent.
In vitro	4-Hydroxytolbutamide is the primary metabolite of tolbutamide, formed via CYP2C9 in humans and CYP2C11 in rats. In rat liver microsomes, the hydroxylation of tolbutamide follows typical Michaelis–Menten kinetics, indicating enzyme-mediated metabolism. [1]
In vivo	In poloxamer 407-induced hyperlipidemic rats, intravenous or oral administration of tolbutamide (10 mg/kg) produced significantly lower AUC values for 4-Hydroxytolbutamide compared to normal rats, indicating reduced metabolic conversion. [2]
Synonyms	Hydroxytolbutamide

Chemical Properties

Molecular Weight	286.35
Formula	C₁₂H₁₈N₂O₄S
Cas No.	5719-85-7
Smiles	O=C(NCCCC)NS(=O)(=O)C1=CC=C(C=C1)CO
Relative Density.	1.268 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (349.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4922 mL	17.4611 mL	34.9223 mL	174.6115 mL
5 mM	0.6984 mL	3.4922 mL	6.9845 mL	34.9223 mL
10 mM	0.3492 mL	1.7461 mL	3.4922 mL	17.4611 mL
20 mM	0.1746 mL	0.8731 mL	1.7461 mL	8.7306 mL
50 mM	0.0698 mL	0.3492 mL	0.6984 mL	3.4922 mL
100 mM	0.0349 mL	0.1746 mL	0.3492 mL	1.7461 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc