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4-Hydroxytolbutamide
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Catalog No. T14040Cas No. 5719-85-7
Alias Hydroxytolbutamide
4-Hydroxytolbutamide is a sulfonylurea and drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 Tolbutamide (HLS 831) is a sulfonylurea hypoglycemic agent.
4-Hydroxytolbutamide
😃Good
Catalog No. T14040Alias HydroxytolbutamideCas No. 5719-85-7
4-Hydroxytolbutamide is a sulfonylurea and drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 Tolbutamide (HLS 831) is a sulfonylurea hypoglycemic agent.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | TBD | 35 days | |
| 5 mg | TBD | 35 days | |
| 10 mg | TBD | 35 days | |
| 25 mg | TBD | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 4-Hydroxytolbutamide is a sulfonylurea and drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 Tolbutamide (HLS 831) is a sulfonylurea hypoglycemic agent. |
| In vitro | 4-Hydroxytolbutamide is the primary metabolite of tolbutamide, formed via CYP2C9 in humans and CYP2C11 in rats. In rat liver microsomes, the hydroxylation of tolbutamide follows typical Michaelis–Menten kinetics, indicating enzyme-mediated metabolism. [1] |
| In vivo | In poloxamer 407-induced hyperlipidemic rats, intravenous or oral administration of tolbutamide (10 mg/kg) produced significantly lower AUC values for 4-Hydroxytolbutamide compared to normal rats, indicating reduced metabolic conversion. [2] |
| Alias | Hydroxytolbutamide |
| Molecular Weight | 286.35 |
| Formula | C12H18N2O4S |
| Cas No. | 5719-85-7 |
| Smiles | O=C(NCCCC)NS(=O)(=O)C1=CC=C(C=C1)CO |
| Relative Density. | 1.268 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (349.22 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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