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Zoledronic acid monohydrate

Name: Zoledronic acid monohydrate
Brand: TargetMol
SKU: T21299
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21299Cas No. 165800-06-6

Alias Zoledronic acid hydrate, zoledronate, ZOL 446, CGP42446A, CGP 42446

Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.

Zoledronic acid monohydrate

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Purity: 99.91%

Catalog No. T21299Alias Zoledronic acid hydrate, zoledronate, ZOL 446, CGP42446A, CGP 42446Cas No. 165800-06-6

Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$34	In Stock	In Stock
25 mg	$53	In Stock	In Stock
50 mg	$77	In Stock	In Stock
100 mg	$127	In Stock	In Stock
500 mg	$178	In Stock	In Stock
1 g	$198	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Zoledronic acid monohydrate AI Summary

Zoledronic acid monohydrate is a multifaceted agent demonstrating significant bioactivities across various biological systems. Notably, it exhibits potent inhibition of osteoclastic bone resorption in rats with an effective dose of 0.0001 mg/kg and an IC50 of 0.2399 nM. The compound shows strong inhibitory activity against human recombinant FPPS (Farnesyl Pyrophosphate Synthase) with an IC50 of 3.0 nM to 4.1 nM, suggesting its potential for therapeutic applications in bone metabolism-related conditions. Additionally, Zoledronic acid monohydrate has antiproliferative effects on various cancer cell lines, including human KB (nasopharyngeal carcinoma) cells with an LD50 of 63.7 µM and other cancer cell lines with IC50 values ranging from 10000.0 nM to 61582.0 nM. It inhibits human Gamma delta T cells, human GGPPS, and demonstrates cytotoxicity against RPMI8226 cells with an EC50 of 11000.0 nM after 72 hours. The compound also presents antimicrobial properties, inhibiting the growth of Entamoeba histolytica (IC50 of 12000.0 nM), Plasmodium falciparum (IC50 of up to 167000.0 nM), Leishmania major FPPS (Ki of 11.0 nM), Toxoplasma gondii FPPS (IC50 of 70.0 nM), and Trypanosoma brucei. It shows selective toxicity toward certain human cancer cells like BXPC-3, CFPAC-1, and PANC-1, with similar IC50 values of 10000.0 nM. Moreover, Zoledronic acid monohydrate has shown antiviral activity against SARS-CoV-2 by inhibiting its induced cytotoxicity in VERO-6 cells. It exerts inhibitory effects on multiple human recombinant carbonic anhydrase isoforms (CA1, CA2, CA9, CA12, CA14) with IC50 values as low as 62.0 nM. In summary, Zoledronic acid monohydrate demonstrates a broad spectrum of bioactivities including bone resorption inhibition, antiproliferative effects on cancer cells, antimicrobial and antiviral properties, and inhibition of various enzymes critical for disease mechanisms..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.
Synonyms	Zoledronic acid hydrate, zoledronate, ZOL 446, CGP42446A, CGP 42446

Chemical Properties

Molecular Weight	290.1
Formula	C₅H₁₂N₂O₈P₂
Cas No.	165800-06-6
Smiles	OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1.[H]O[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

0.1M NaOH: 10 mg/mL (34.47 mM), Sonication and heating are recommended.

H2O: Insoluble

Solution Preparation Table

0.1M NaOH

	1mg	5mg	10mg	50mg
1 mM	3.4471 mL	17.2354 mL	34.4709 mL	172.3544 mL
5 mM	0.6894 mL	3.4471 mL	6.8942 mL	34.4709 mL
10 mM	0.3447 mL	1.7235 mL	3.4471 mL	17.2354 mL
20 mM	0.1724 mL	0.8618 mL	1.7235 mL	8.6177 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc