Shopping Cart

Your shopping cart is currently empty

Monacolin J

Name: Monacolin J
Brand: TargetMol
SKU: T12092
Price: 72 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T12092Cas No. 79952-42-4

Alias Lovastatin diol lactone, Antibiotic MB 530A

Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.

Monacolin J

😃Good

Purity: 98.06%

Catalog No. T12092Alias Lovastatin diol lactone, Antibiotic MB 530ACas No. 79952-42-4

Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$72	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$247	In Stock	In Stock
25 mg	$418	In Stock	In Stock
50 mg	$596	-	In Stock
100 mg	$863	-	In Stock
1 mL x 10 mM (in DMSO)	$173	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.06%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.
In vitro	Monacolin J is a cholesterol biosynthesis inhibitor, and inhibits the activity of HMG-CoA reductase. Na salt of Monacolin J causes 50% inhibition on reductase at 1.2 μg/mL[1].
Synonyms	Lovastatin diol lactone, Antibiotic MB 530A

Chemical Properties

Molecular Weight	320.42
Formula	C₁₉H₂₈O₄
Cas No.	79952-42-4
Smiles	C(C[C@@H]1C[C@@H](O)CC(=O)O1)[C@@H]2[C@@]3(C(C=C[C@@H]2C)=C[C@H](C)C[C@@H]3O)[H]
Relative Density.	1.17 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (171.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1209 mL	15.6045 mL	31.2090 mL	156.0452 mL
5 mM	0.6242 mL	3.1209 mL	6.2418 mL	31.2090 mL
10 mM	0.3121 mL	1.5605 mL	3.1209 mL	15.6045 mL
20 mM	0.1560 mL	0.7802 mL	1.5605 mL	7.8023 mL
50 mM	0.0624 mL	0.3121 mL	0.6242 mL	3.1209 mL
100 mM	0.0312 mL	0.1560 mL	0.3121 mL	1.5605 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc