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Monacolin J

Name: Monacolin J
Brand: TargetMol
SKU: T12092
Price: 72 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12092Cas No. 79952-42-4

Alias Lovastatin diol lactone, Antibiotic MB 530A

Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.

Monacolin J

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Purity: 98.06%

Catalog No. T12092Alias Lovastatin diol lactone, Antibiotic MB 530ACas No. 79952-42-4

Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.

Pack Size	Price	Availability
1 mg	$72	In Stock
5 mg	$163	In Stock
10 mg	$247	In Stock
25 mg	$418	In Stock
50 mg	$596	In Stock
100 mg	$863	In Stock
1 mL x 10 mM (in DMSO)	$173	In Stock

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Batch Information

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Purity:98.06%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.
In vitro	Monacolin J is a cholesterol biosynthesis inhibitor, and inhibits the activity of HMG-CoA reductase. Na salt of Monacolin J causes 50% inhibition on reductase at 1.2 μg/mL[1].
Synonyms	Lovastatin diol lactone, Antibiotic MB 530A

Chemical Properties

Molecular Weight	320.42
Formula	C₁₉H₂₈O₄
Cas No.	79952-42-4
Smiles	C(C[C@@H]1C[C@@H](O)CC(=O)O1)[C@@H]2[C@@]3(C(C=C[C@@H]2C)=C[C@H](C)C[C@@H]3O)[H]
Relative Density.	1.17 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (171.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1209 mL	15.6045 mL	31.2090 mL	156.0452 mL
5 mM	0.6242 mL	3.1209 mL	6.2418 mL	31.2090 mL
10 mM	0.3121 mL	1.5605 mL	3.1209 mL	15.6045 mL
20 mM	0.1560 mL	0.7802 mL	1.5605 mL	7.8023 mL
50 mM	0.0624 mL	0.3121 mL	0.6242 mL	3.1209 mL
100 mM	0.0312 mL	0.1560 mL	0.3121 mL	1.5605 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc