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LQZ-7F

Catalog No. T61184 CAS 354543-09-2

LQZ-7F is a small molecule survivin dimerisation inhibitor with anticancer activity.LQZ-7F induces proteasome-dependent survivin degradation, mitotic arrest, and apoptosis, and blocks human tumour growth in mouse xenograft assays.

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LQZ-7F, CAS 354543-09-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 483.00
10 mg	In stock	$ 692.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,490.00
100 mg	In stock	$ 1,970.00
500 mg	In stock	$ 3,930.00

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Purity: 98.64%

Biological Description

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Storage & Solubility Information

Description	LQZ-7F is a small molecule survivin dimerisation inhibitor with anticancer activity.LQZ-7F induces proteasome-dependent survivin degradation, mitotic arrest, and apoptosis, and blocks human tumour growth in mouse xenograft assays.
In vitro	LQZ-7F and LQZ-7F1 treatment at 2.5 μM for 72 hours inhibited the viability of prostate cancer cell lines PC-3 and C4-2, as determined by MTT assay.
In vivo	LQZ-7F was administered at 25 mg/kg via intraperitoneal injection once every 3 days for a total of 8 treatments. On the 30th day after treatment, it was found to inhibit the growth of xenograft tumors[1].

Molecular Weight	349.26
Formula	C14H7N9O3
CAS No.	354543-09-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2 mg/mL (5.73 mM), Sonication is recommended.

References and Literature

1. Robert Peery, et al. A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. Bioorg Med Chem. 2022 Jul 1;65:116761. 2. Qi Jing, et al. Effective Targeting of the Survivin Dimerization Interface with Small-Molecule Inhibitors. Cancer Research. 2016 Jan. 76(2):453-462.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LQZ-7F 354543-09-2 Apoptosis Survivin inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.