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Anti-Nicastrin Antibody (1O43)
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Catalog No. TMAB-09473 Copy Product Info
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Anti-Nicastrin Antibody (1O43) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (1O43) can be used in WB.
Anti-Nicastrin Antibody
(1O43)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 µL | $150 | 7-10 days | 7-10 days | |
| 50 µL | $261 | 7-10 days | 7-10 days | |
| 100 µL | $472 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Nicastrin Antibody (1O43) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (1O43) can be used in WB. |
| Ig Type | IgG |
| Clone | 1O43 |
| Reactivity | Human |
| Verified Activity | 25 μg total protein per lane of various lysates (see on figure) probed with Nicastrin monoclonal antibody, unconjugated (TMAB-09473) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Specificity | Widely expressed. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. |
| Immunogen | A synthesized peptide: human Nicastrin |
| Antigen Species | Human |
| Gene Name | NCSTN |
| Gene ID | |
| Protein Name | Nicastrin |
| Uniprot ID | |
| Function | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. |
| Molecular Weight | Theoretical: 78 kDa. Actual: 120 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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