IGF1/IGF-I Protein, Human, Recombinant V2

Name: IGF1/IGF-I Protein, Human, Recombinant V2
Brand: TargetMol
SKU: TMPY-06982U
Rating: 4.5 (1 reviews)

(Synonyms: somatomedin C, MGF, insulin-like growth factor 1, IGF‑I, IGF-I, IGFI, IGF1A, IGF-1) Copy Product Info

Synonyms: somatomedin C, MGF, insulin-like growth factor 1, IGF‑I, IGF-I, IGFI, IGF1A, IGF-1

Catalog No. TMPY-06982U Copy Product Info

IGF1/IGF-I Protein, Human, Recombinant V2 is expressed in E. coli. The accession number is P05019.

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Pack Size	Price	USA Stock	Global Stock
5 µg	Preferential	7-10 days	7-10 days
10 µg	$38	7-10 days	7-10 days
20 µg	$58	7-10 days	7-10 days
50 µg	$108	7-10 days	7-10 days
100 µg	$176	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 10^5 IU/mg.
Description	IGF1/IGF-I Protein, Human, Recombinant V2 is expressed in E. coli. The accession number is P05019.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P05019
Amino Acid	GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Construction	Gly49-Ala118
Protein Purity	> 97% as determined by SDS-PAGE; > 95% as determined by HPLC
Endotoxin	< 0.01 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.0.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water or aqueous buffer containing 0.1 % BSA. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	somatomedin C, MGF, insulin-like growth factor 1, IGF‑I, IGF-I, IGFI, IGF1A, IGF-1
Research Background	The insulin-like growth factors (IGFs) belonged to the insulin gene family, are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. The production of IGF-1 is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B. Recombinant human IGF-1 are globular proteins containing 70 amino acids and 3 intra-molecular disulfide bonds. Mature human IGF-1 shares 94 % and 96 % a.a. sequence identity with mouse and rat IGF-1, respectively, and exhibits cross-species activity.

Chemical Properties

Molecular Weight

7.6 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.