Shopping Cart

Your shopping cart is currently empty

Metamizole sodium

Name: Metamizole sodium
Brand: TargetMol
SKU: T1191L
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T1191LCas No. 68-89-3

Alias Dipyron, Analgin

Metamizole sodium (Analgin) is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.

Metamizole sodium

Copy Product Info

🥰Excellent

Purity: 99.85%

Catalog No. T1191LAlias Dipyron, AnalginCas No. 68-89-3

Metamizole sodium (Analgin) is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Metamizole sodium AI Summary

Metamizole sodium exhibits a wide range of bioactivity and pharmacological effects. In various pain models, it demonstrates significant antinociceptive properties. In Swiss and albino mice, it shows a notable inhibition of acetic acid-induced abdominal constrictions and formalin-induced paw pain, with ED50 and ID50 values indicating effective doses for this activity. It also increases the reaction time for tail flicking in albino Wistar rats at 25 mg/kg, administered orally. In locomotor activity tests with albino mice, Metamizole sodium induces increased movement, measured at 87.7 crossings at a dose of 1000 µmol/kg. Additionally, Metamizole sodium shows extensive bioactivity as an enzyme and viral inhibitor, demonstrating inhibition of JMJD2E, Tau fibril formation, various human lipoxygenases (12-hLO, 15-hLO, and 15-hLO-2), GCN5L2, polymerase iota, USP1/UAF1, glutaminase, hepatitis C virus, and the entry of the Ebola virus, among others. It also displays moderate liver toxicity, evident from elevated serum enzyme activities and potential acute liver toxicity. Moreover, Metamizole sodium inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, showing significant inhibition rates. It also exhibits prodrug activation in FAAH knock-out C57BL/6 mice brains, resulting in the formation of specific metabolites. Overall, Metamizole sodium presents potential as an analgesic, anti-inflammatory, and bioactive agent against various enzymatic and viral targets, with noted effects on physiological parameters and moderate liver toxicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Metamizole sodium (Analgin) is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
Synonyms	Dipyron, Analgin

Chemical Properties

Molecular Weight	333.34
Formula	C₁₃H₁₆N₃NaO₄S
Cas No.	68-89-3
Smiles	[Na+].CN(CS([O-])(=O)=O)c1c(C)n(C)n(-c2ccccc2)c1=O
Relative Density.	1.388 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (180 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9999 mL	14.9997 mL	29.9994 mL	149.9970 mL
5 mM	0.6000 mL	2.9999 mL	5.9999 mL	29.9994 mL
10 mM	0.3000 mL	1.5000 mL	2.9999 mL	14.9997 mL
20 mM	0.1500 mL	0.7500 mL	1.5000 mL	7.4999 mL
50 mM	0.0600 mL	0.3000 mL	0.6000 mL	2.9999 mL
100 mM	0.0300 mL	0.1500 mL	0.3000 mL	1.5000 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc