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URAT1 inhibitor 7

Name: URAT1 inhibitor 7
Brand: TargetMol
SKU: T77517
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77517Cas No. 1632002-28-8

URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 μM.URAT1 inhibitor 7 can be used to study hyperuricemia and gout.

URAT1 inhibitor 7

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Purity: 97.14%

Catalog No. T77517Cas No. 1632002-28-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
5 mg	$483	In Stock	In Stock
10 mg	$692	In Stock	In Stock
25 mg	$1,080	In Stock	In Stock
50 mg	$1,490	In Stock	In Stock
100 mg	$1,970	In Stock	In Stock
500 mg	$3,930	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.14%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

URAT1 inhibitor 7 AI Summary

URAT1 inhibitor 7 exhibits a wide range of bioactivities. It has a renal clearance of 0.0001 mL.min-1.kg-1 in both dogs and rats, and an oral bioavailability of 100.0% in rats at various doses. The volume of distribution at steady state in rats varies between 0.18 and 0.25 L.kg-1, with a half-life ranging from 6.7 to 7.1 hours. The compound shows unbound clearance rates between 95.0 and 229.0 mL.min-1.kg-1 and a plasma clearance of 0.39 mL.min-1.kg-1 in rats. It inhibits enzymes such as CYP2D6, CYP2C19, CYP2C9, and CYP2C8, with IC50 values ranging from 4200.0 to 17500.0 nM. In terms of cytotoxicity, URAT1 inhibitor 7 has an activity of 103.0 uM against THLE cells. It inhibits transporters like OAT4, OAT3, and OAT1 with IC50 values between 720.0 and 14000.0 nM and has a low fraction unbound in plasma. The compound's solubility is 7700.0 nM at pH 6.5. Toxicity assessments show an MTD of 100.0 mg kg-1 in po dosed rats and activity ≤ 300.0 mg kg-1 in po dosed dogs. URAT1 inhibitor 7 also inhibits the GABAA receptor with a Ki value of 4800.0 nM and exhibits substrate activity at BCRP and p-gp, with efflux ratios of 122.0 and 3.5, respectively. Additionally, URAT1 inhibitor 7 has shown an IC50 value of 13.0 nM in an inhibition assay and demonstrates inhibitory activity on uric acid transport within the 0 to 10 uM concentration range, pre-incubated and compared against a vehicle (DMSO) and a pharmacological blockade (benzbromarone)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	428.82
Formula	C₁₉H₁₀ClFN₄O₃S
Cas No.	1632002-28-8
Smiles	N#CC1=CC=C(OC2=CC=C(C=C2C#N)S(=O)(=O)NC3=NC=C(F)C=C3)C=C1Cl
Relative Density.	1.58 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (116.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3320 mL	11.6599 mL	23.3198 mL	116.5990 mL
5 mM	0.4664 mL	2.3320 mL	4.6640 mL	23.3198 mL
10 mM	0.2332 mL	1.1660 mL	2.3320 mL	11.6599 mL
20 mM	0.1166 mL	0.5830 mL	1.1660 mL	5.8300 mL
50 mM	0.0466 mL	0.2332 mL	0.4664 mL	2.3320 mL
100 mM	0.0233 mL	0.1166 mL	0.2332 mL	1.1660 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc