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LIT-001

🥰Excellent
Catalog No. T11857Cas No. 2245072-21-1

LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.

LIT-001
Other Forms of LIT-001:
LIT-001 free baseT118562245072-20-0
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LIT-001

🥰Excellent
Purity: 98.25%
Catalog No. T11857Cas No. 2245072-21-1
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
Pack SizePriceAvailabilityQuantity
1 mg$52In Stock
5 mg$123In Stock
10 mg$198In Stock
25 mg$372In Stock
50 mg$538In Stock
100 mg$787In Stock
200 mg$1,070In Stock
1 mL x 10 mM (in DMSO)$175In Stock
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Batch Information

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Purity:98.25%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
Targets&IC50
OTR:226 nM (Ki), OTR:55 nM (EC50)
In vitro
In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration.
In vivo
LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms of autism spectrum disorders (ASD) [1].
Chemical Properties
Molecular Weight645.7
FormulaC30H34F3N7O4S
Cas No.2245072-21-1
SmilesOC(=O)C(F)(F)F.CN(C)C(=S)[C@@H]1CCCN1C(=O)NCc1ccc(cc1C)C(=O)N1Cc2cnn(C)c2Nc2ccccc12
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 247 mg/mL (382.53 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5487 mL7.7435 mL15.4871 mL77.4353 mL
5 mM0.3097 mL1.5487 mL3.0974 mL15.4871 mL
10 mM0.1549 mL0.7744 mL1.5487 mL7.7435 mL
20 mM0.0774 mL0.3872 mL0.7744 mL3.8718 mL
50 mM0.0310 mL0.1549 mL0.3097 mL1.5487 mL
100 mM0.0155 mL0.0774 mL0.1549 mL0.7744 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

vasopressinV1aspectrumsocialreceptorOxytocinReceptorOxytocin Receptoroxytocin receptorOXTROT-RnonpeptidenonbiasedLIT-001LIT001LIT 001interactionInhibitorinhibitdisordersautism
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