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Anti-AURKB Antibody (8S661)
(Synonyms: STK5, STK12, STK-1, STK1, Serine/threonine-protein kinase aurora-B, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase 12, EC 2.7.11.1, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, Aurora kinase B, Aurora- and IPL1-like midbody-associated protein 1, Aurora 1, ARK-2, ARK2, AIRK2, AIM-1, AIM1, AIK2) Copy Product Info
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Synonyms: STK5, STK12, STK-1, STK1, Serine/threonine-protein kinase aurora-B, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase 12, EC 2.7.11.1, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, Aurora kinase B, Aurora- and IPL1-like midbody-associated protein 1, Aurora 1, ARK-2, ARK2, AIRK2, AIM-1, AIM1, AIK2
Catalog No. TMAH-00097 Copy Product Info
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Anti-AURKB Antibody (8S661) is an antibody targeting AURKB. Anti-AURKB Antibody (8S661) can be used in ELISA,IHC,IP,WB.
Anti-AURKB Antibody
(8S661)
(8S661)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $207 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-AURKB Antibody (8S661) is an antibody targeting AURKB. Anti-AURKB Antibody (8S661) can be used in ELISA,IHC,IP,WB. |
| Synonyms | STK5, STK12, STK-1, STK1, Serine/threonine-protein kinase aurora-B, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase 12, EC 2.7.11.1, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, Aurora kinase B, Aurora- and IPL1-like midbody-associated protein 1, Aurora 1, ARK-2, ARK2, AIRK2, AIM-1, AIM1, AIK2 |
| Ig Type | Rabbit IgG |
| Clone | 8S661 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200; IP:1:200-1:1000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. |
| Tissue Specificity | High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Aurora B |
| Antigen Species | Human |
| Gene Name | AURKB |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Cancer, Cell biology, Signal transduction |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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