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Acetyl Angiotensinogen (1-14), porcine Acetate

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Catalog No. T21582L
Alias Acetyl Angiotensinogen (1-14), porcine Acetate(66641-26-7 Free base)

Acetyl Angiotensinogen (1-14), porcine Acetate is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor. 

Acetyl Angiotensinogen (1-14), porcine Acetate

Acetyl Angiotensinogen (1-14), porcine Acetate

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Purity: 95.71%
Catalog No. T21582LAlias Acetyl Angiotensinogen (1-14), porcine Acetate(66641-26-7 Free base)
Acetyl Angiotensinogen (1-14), porcine Acetate is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor. 
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$31In StockIn Stock
25 mg$41In StockIn Stock
50 mg$66In StockIn Stock
1 mL x 10 mM (in DMSO)$48In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:95.71%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Acetyl Angiotensinogen (1-14), porcine Acetate is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor. 
In vitro
The renin-angiotensin system?was extracted from blood with 70% acetone and had a short pressor effect.?The renin acted enzymatically on a plasma protein to produce the new substance.?
In vivo
The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor.?Pre-angiotensinogen is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure.?The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II.?Angiotensin II is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia[2].
SynonymsAcetyl Angiotensinogen (1-14), porcine Acetate(66641-26-7 Free base)
Chemical Properties
Molecular Weight1861.1
FormulaC89H129N21O23
SmilesO=C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC=N2)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C.CC(O)=O
Relative Density.no data available
SequenceAc-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH.
Sequence ShortDRVYIHPFHLLVYS
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 162 mg/mL (87.05 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.5373 mL2.6866 mL5.3732 mL26.8658 mL
5 mM0.1075 mL0.5373 mL1.0746 mL5.3732 mL
10 mM0.0537 mL0.2687 mL0.5373 mL2.6866 mL
20 mM0.0269 mL0.1343 mL0.2687 mL1.3433 mL
50 mM0.0107 mL0.0537 mL0.1075 mL0.5373 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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