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Agomelatine (Alias: Valdoxan, Thymanax, S-20098)

Name: Agomelatine
Brand: TargetMol
SKU: T1445
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T1445 Copy Product Info

Purity: 99.92%

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Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.

Agomelatine

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Catalog No. T1445

Alias Valdoxan, Thymanax, S-20098

Cas No. 138112-76-2

Pack Size	Price	USA Stock	Global Stock
2 mg	$30	In Stock	In Stock
5 mg	$44	In Stock	In Stock
10 mg	$60	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$189	In Stock	In Stock
100 mg	$263	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.92%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
Targets&IC50	MT2 (human):0.12 nM (Ki, CHO Cells), MT2 (human):0.27 nM (Ki, HEK Cells), MT1 (human):0.06 nM (Ki, HEK Cells), MT1 (human):0.1 nM (Ki, CHO Cells), 5-HT2C (porcine):6.4(pKi), 5-HT2C (human):6.2(pKi)
In vitro	Agomelatine enhances cell proliferation and neurogenesis in the ventral hippocampus (VH) of adult rats, a region associated with emotional disorders. It effectively reverses behavior alterations in transgenic mice observed in Porsolt forced swimming tests and elevated plus mazes. Agomelatine significantly accelerates the re-adjustment of circadian rhythms of temperature and activity after induced phase shifts. It increases the duration of positive social interactions in mice exposed to new environments. In the ventral dentate gyrus of rats, which is involved in emotional responses, Agomelatine promotes cell proliferation and neurogenesis, consistent with its anti-depressant and anti-anxiety properties. Across the entire dentate gyrus, Agomelatine boosts the survival of newly generated neurons. It enhances the ratio of mature to immature neurons and promotes dendritic sprouting in the granule cells of adult rats, indicating accelerated maturation. Furthermore, Agomelatine activates several cellular signaling pathways (extracellular signal-regulated kinases 1/2, protein kinase B, and glycogen synthase kinase 3 beta) known to be modulated by antidepressants and involved in proliferation/survival control.
In vivo	In mice subjected to chronic electroshock stress, Agomelatine fully normalized the survival of stress-affected cells in the hippocampus and partially reversed the reduction in glucocorticoid receptor expression.
Synonyms	Valdoxan, Thymanax, S-20098

Chemical Properties

Molecular Weight	243.30
Formula	C₁₅H₁₇NO₂
Cas No.	138112-76-2
Smiles	COC1=CC=C2C=CC=C(CCNC(C)=O)C2=C1
Relative Density.	1.109g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250.00 mg/mL (1027.54 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 42.00 mg/mL (172.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (8.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1102 mL	20.5508 mL	41.1015 mL	205.5076 mL
5 mM	0.8220 mL	4.1102 mL	8.2203 mL	41.1015 mL
10 mM	0.4110 mL	2.0551 mL	4.1102 mL	20.5508 mL
20 mM	0.2055 mL	1.0275 mL	2.0551 mL	10.2754 mL
50 mM	0.0822 mL	0.4110 mL	0.8220 mL	4.1102 mL
100 mM	0.0411 mL	0.2055 mL	0.4110 mL	2.0551 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc