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SPDP-C6-NHS ester

🥰Excellent
Catalog No. T16915Cas No. 158913-22-5

SPDP-C6-NHS ester is an alkyl/ether-based linker used in the synthesis of PROTACs. PROTAC molecules contain two ligands joined by a linker: one ligand recruits an E3 ubiquitin ligase and the other binds to a target protein. SPDP-C6-NHS ester enables selective degradation of target proteins by exploiting the ubiquitin-proteasome system.

SPDP-C6-NHS ester

SPDP-C6-NHS ester

🥰Excellent
Purity: 98.96%
Catalog No. T16915Cas No. 158913-22-5
SPDP-C6-NHS ester is an alkyl/ether-based linker used in the synthesis of PROTACs. PROTAC molecules contain two ligands joined by a linker: one ligand recruits an E3 ubiquitin ligase and the other binds to a target protein. SPDP-C6-NHS ester enables selective degradation of target proteins by exploiting the ubiquitin-proteasome system.
Pack SizePriceAvailabilityQuantity
5 mg$36In Stock
10 mg$51In Stock
25 mg$83In Stock
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Purity:98.96%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
SPDP-C6-NHS ester is an alkyl/ether-based linker used in the synthesis of PROTACs. PROTAC molecules contain two ligands joined by a linker: one ligand recruits an E3 ubiquitin ligase and the other binds to a target protein. SPDP-C6-NHS ester enables selective degradation of target proteins by exploiting the ubiquitin-proteasome system.
Chemical Properties
Molecular Weight425.52
FormulaC18H23N3O5S2
Cas No.158913-22-5
SmilesO=C(ON1C(=O)CCC1=O)CCCCCNC(=O)CCSSC2=NC=CC=C2
Relative Density.1.36g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (94 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.7 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3501 mL11.7503 mL23.5007 mL117.5033 mL
5 mM0.4700 mL2.3501 mL4.7001 mL23.5007 mL
10 mM0.2350 mL1.1750 mL2.3501 mL11.7503 mL
20 mM0.1175 mL0.5875 mL1.1750 mL5.8752 mL
50 mM0.0470 mL0.2350 mL0.4700 mL2.3501 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SPDP-C6-NHS esterSPDP-C-6-NHS esterSPDPC6NHS esterSPDP C6 NHS esterAlkyl/ether
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