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SPDP-C6-NHS ester

Name: SPDP-C6-NHS ester
Brand: TargetMol
SKU: T16915
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16915Cas No. 158913-22-5

SPDP-C6-NHS ester is an alkyl/ether-based linker used in the synthesis of PROTACs. PROTAC molecules contain two ligands joined by a linker: one ligand recruits an E3 ubiquitin ligase and the other binds to a target protein. SPDP-C6-NHS ester enables selective degradation of target proteins by exploiting the ubiquitin-proteasome system.

SPDP-C6-NHS ester

🥰Excellent

Purity: 98.96%

Catalog No. T16915Cas No. 158913-22-5

Pack Size	Price	Availability
5 mg	$36	In Stock
10 mg	$51	In Stock
25 mg	$83	In Stock

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Batch Information

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Purity:98.96%

Resource Download

COA LCMS HNMR LCMS

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	425.52
Formula	C₁₈H₂₃N₃O₅S₂
Cas No.	158913-22-5
Relative Density.	1.36g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3501 mL	11.7503 mL	23.5007 mL	117.5033 mL
5 mM	0.4700 mL	2.3501 mL	4.7001 mL	23.5007 mL
10 mM	0.2350 mL	1.1750 mL	2.3501 mL	11.7503 mL
20 mM	0.1175 mL	0.5875 mL	1.1750 mL	5.8752 mL
50 mM	0.0470 mL	0.2350 mL	0.4700 mL	2.3501 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc