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PROTAC PD-L1 degrader-1
🥰Excellent
Catalog No. T210164
PROTACPD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with significant PD-L1 protein degradation capacity. It demonstrates strong PD-L1 degradation activity in 4T1 cells, with a DC50 of 0.609 μM. This compound is applicable to breast cancer research.
PROTAC PD-L1 degrader-1
PROTAC PD-L1 degrader-1
🥰Excellent
Catalog No. T210164
PROTACPD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with significant PD-L1 protein degradation capacity. It demonstrates strong PD-L1 degradation activity in 4T1 cells, with a DC50 of 0.609 μM. This compound is applicable to breast cancer research.
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTACPD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with significant PD-L1 protein degradation capacity. It demonstrates strong PD-L1 degradation activity in 4T1 cells, with a DC50 of 0.609 μM. This compound is applicable to breast cancer research. |
| Targets&IC50 | Cereblon:131.77 μM (kd) |
| In vitro | PROTAC PD-L1 degrader-1 (compound PA8; 0.078-10 μM; 24 hours) significantly degrades PD-L1 protein in 4T1 cells in a dose-dependent manner. It exhibits specific binding to CRBN and PD-L1 with dissociation constant (K d) values of 131.77 μM and 59.2 μM, respectively, both showing concentration dependency. |
| In vivo | PROTAC PD-L1 degrader-18 (30-60 mg/kg; intraperitoneal injection; once daily for 15 days) effectively reduces both tumor volume and weight in a 4T1 tumor-bearing mouse model. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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