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A-1211212

Name: A-1211212
Brand: TargetMol
SKU: T10484
Price: 108 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10484Cas No. 1257044-75-9

Alias BCL2-IN-1

A-1211212 (BCL2-IN-1) is a potent and selective Bcl-2 inhibitor. It promotes lymphocyte apoptosis, alters colonic mucosa in mice, and improves inflammation.

A-1211212

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Purity: 99.75%

Catalog No. T10484Alias BCL2-IN-1Cas No. 1257044-75-9

A-1211212 (BCL2-IN-1) is a potent and selective Bcl-2 inhibitor. It promotes lymphocyte apoptosis, alters colonic mucosa in mice, and improves inflammation.

Pack Size	Price	Availability
1 mg	$108	In Stock
5 mg	$268	In Stock
10 mg	$428	In Stock
25 mg	$868	In Stock
1 mL x 10 mM (in DMSO)	$423	In Stock

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Purity:99.75%

ee:100%

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Product Introduction

Bioactivity

Description	A-1211212 (BCL2-IN-1) is a potent and selective Bcl-2 inhibitor. It promotes lymphocyte apoptosis, alters colonic mucosa in mice, and improves inflammation.
In vitro	A-1211212 is a potent Bcl-2 inhibitor that binds to Bcl-2 with a Ki value of <0.01 nM. [1]
Synonyms	BCL2-IN-1

Chemical Properties

Molecular Weight	896.49
Formula	C₄₇H₅₄ClN₇O₇S
Cas No.	1257044-75-9
Smiles	C(C1=C(CC(C)(C)CC1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC(OC=5C=C6C(=NC5)NC=C6)=C(C(NS(=O)(=O)C7=CC(N(=O)=O)=C(NC[C@H]8CC[C@H](OC)CC8)C=C7)=O)C=C4
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (111.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1155 mL	5.5773 mL	11.1546 mL	55.7731 mL
5 mM	0.2231 mL	1.1155 mL	2.2309 mL	11.1546 mL
10 mM	0.1115 mL	0.5577 mL	1.1155 mL	5.5773 mL
20 mM	0.0558 mL	0.2789 mL	0.5577 mL	2.7887 mL
50 mM	0.0223 mL	0.1115 mL	0.2231 mL	1.1155 mL
100 mM	0.0112 mL	0.0558 mL	0.1115 mL	0.5577 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc