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A-1211212

Name: A-1211212
Brand: TargetMol
SKU: T10484
Price: 108 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10484Cas No. 1257044-75-9

Alias BCL2-IN-1

A-1211212 (BCL2-IN-1) is a potent and selective Bcl-2 inhibitor. It promotes lymphocyte apoptosis, alters colonic mucosa in mice, and improves inflammation.

A-1211212

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Purity: 99.75%

Catalog No. T10484Alias BCL2-IN-1Cas No. 1257044-75-9

A-1211212 (BCL2-IN-1) is a potent and selective Bcl-2 inhibitor. It promotes lymphocyte apoptosis, alters colonic mucosa in mice, and improves inflammation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$108	In Stock	In Stock
5 mg	$268	In Stock	In Stock
10 mg	$428	In Stock	In Stock
25 mg	$868	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$423	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

ee:100%

Appearance:Solid

Color:White to Yellow

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	A-1211212 (BCL2-IN-1) is a potent and selective Bcl-2 inhibitor. It promotes lymphocyte apoptosis, alters colonic mucosa in mice, and improves inflammation.
In vitro	A-1211212 is a potent Bcl-2 inhibitor that binds to Bcl-2 with a Ki value of <0.01 nM. [1]
Synonyms	BCL2-IN-1

Chemical Properties

Molecular Weight	896.49
Formula	C₄₇H₅₄ClN₇O₇S
Cas No.	1257044-75-9
Smiles	C(C1=C(CC(C)(C)CC1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC(OC=5C=C6C(=NC5)NC=C6)=C(C(NS(=O)(=O)C7=CC(N(=O)=O)=C(NC[C@H]8CC[C@H](OC)CC8)C=C7)=O)C=C4
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (111.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1155 mL	5.5773 mL	11.1546 mL	55.7731 mL
5 mM	0.2231 mL	1.1155 mL	2.2309 mL	11.1546 mL
10 mM	0.1115 mL	0.5577 mL	1.1155 mL	5.5773 mL
20 mM	0.0558 mL	0.2789 mL	0.5577 mL	2.7887 mL
50 mM	0.0223 mL	0.1115 mL	0.2231 mL	1.1155 mL
100 mM	0.0112 mL	0.0558 mL	0.1115 mL	0.5577 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc