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ATN-658
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Catalog No. T9901A-1238 Copy Product Info
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ATN-658 is a humanized monoclonal antibody target the Domain 3 region of the urokinase-type plasminogen activator receptor, inhibition of cellular migration and invasion by disrupting the functional interaction between the receptor and various integrin signaling partners within designated preclinical oncology models.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $278 | Inquiry | Inquiry | |
| 5 mg | $838 | Inquiry | Inquiry | |
| 10 mg | $1,330 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | ATN-658 is a humanized monoclonal antibody target the Domain 3 region of the urokinase-type plasminogen activator receptor, inhibition of cellular migration and invasion by disrupting the functional interaction between the receptor and various integrin signaling partners within designated preclinical oncology models. |
| In vitro | In PC-3 prostate cancer cell assays, ATN-658 caused a significant dose-dependent decrease in cell motility without affecting doubling time [1]. |
| In vivo | In intratibial PC-3 xenograft models, systemic administration of ATN-658 resulted in a significant decrease in tumor volume and skeletal lesions [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | PLAUR/uPAR/CD87 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: ATN-658 chemical structure | ATN-658 in vivo | ATN-658 in vitro
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