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Azelaprag

Azelaprag
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Purity:99.60%
ee:100%
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Azelaprag

Catalog No. T14390Cas No. 2049980-18-7
Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$396In Stock
5 mg$1,180In Stock
10 mg$1,530In Stock
25 mg$2,160In Stock
50 mg$2,800In Stock
1 mL x 10 mM (in DMSO)$1,380In Stock
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Product Introduction

Bioactivity
Description
Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases.
In vivo
In the transgenic Alzheimer's disease animal model (tgAPPSwedish/London), azeliragon (5 mg/day) reduces Aβ plaque deposition, decreases overall Aβ burden while increasing Aβ levels in plasma, lowers sAPPβ and increases sAPPα levels, reduces inflammatory cytokines, slows cognitive decline, and improves cerebral blood flow.[1]
AliasAMG 986
Chemical Properties
Molecular Weight523.61
FormulaC25H29N7O4S
Cas No.2049980-18-7
Storage & Solubility Information
Storage|Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 60 mg/mL (114.59 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9098 mL9.5491 mL19.0982 mL95.4909 mL
5 mM0.3820 mL1.9098 mL3.8196 mL19.0982 mL
10 mM0.1910 mL0.9549 mL1.9098 mL9.5491 mL
20 mM0.0955 mL0.4775 mL0.9549 mL4.7745 mL
50 mM0.0382 mL0.1910 mL0.3820 mL1.9098 mL
100 mM0.0191 mL0.0955 mL0.1910 mL0.9549 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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2 Enter the in vivo formulation:
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