Shopping Cart

Your shopping cart is currently empty

Azelaprag

Name: Azelaprag
Brand: TargetMol
SKU: T14390
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: AMG 986) Copy Product Info

😃Good

Synonyms: AMG 986

Catalog No. T14390 Copy Product Info

Purity: 99.67%

😃Good

Azelaprag (AMG 986) is an oral apelin receptor agonist (EC50 = 0.32 nM). Azelaprag may be used to treat neurological disorders, cardiovascular diseases, and obesity with metabolic syndrome.

Cas No. 2049980-18-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$107	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$413	In Stock	In Stock
25 mg	$629	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$336	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.67%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS CSFC

Product Introduction

Bioactivity

Description	Azelaprag (AMG 986) is an oral apelin receptor agonist (EC50 = 0.32 nM). Azelaprag may be used to treat neurological disorders, cardiovascular diseases, and obesity with metabolic syndrome.
Targets & IC50	RAGE:12.7 ± 7.6 nM (kd), apelin receptor:0.32 nM (EC50)
In vitro	Methods: Primary human ADPKD renal epithelial cells were cultured in 3D collagen matrices and treated with 1 nmol/L to 1 μmol/L of Azelaprag; cyst growth was then assessed. Results: Azelaprag inhibited cyst volume in a dose-dependent manner and reduced the number of cysts. [3]
In vivo	Methods: Pkd1^(RC/RC);Pkd2^(+/-) polycystic kidney mice were administered 2 mg/kg of Azelaprag via intraperitoneal injection daily for 27 days. Results: Azelaprag reduced cyst count but did not significantly improve the corticomedullary ratio, cyst index, or renal function. [3]
Synonyms	AMG 986

Chemical Properties

Molecular Weight	523.61
Formula	C₂₅H₂₉N₇O₄S
Cas No.	2049980-18-7
Smiles	N(S([C@H]([C@H](C)C=1N=CC(C)=CN1)C)(=O)=O)C=2N(C(=NN2)C=3C=C(C)C=NC3)C4=C(OC)C=CC=C4OC
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 69.3 mg/mL (132.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9098 mL	9.5491 mL	19.0982 mL	95.4909 mL
5 mM	0.3820 mL	1.9098 mL	3.8196 mL	19.0982 mL
10 mM	0.1910 mL	0.9549 mL	1.9098 mL	9.5491 mL
20 mM	0.0955 mL	0.4775 mL	0.9549 mL	4.7745 mL
50 mM	0.0382 mL	0.1910 mL	0.3820 mL	1.9098 mL
100 mM	0.0191 mL	0.0955 mL	0.1910 mL	0.9549 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc