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RSV

Human orthopneumovirus (also known as human respiratory syncytial virus, or HRSV, or just RSV) is a syncytial virus that causes respiratory tract infections.

  • Ribavirin
    T068436791-04-5
    Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
    • $39
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  • Roflumilast
    T1024162401-32-3
    Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its active metabolite roflumilast N-oxide selectively and competitively bind to and inhibit PDE4, which leads to an increase of both intracellular levels of cyclic-3', 5'-adenosine monophosphate (cAMP) and cAMP-mediated signaling.
    • $50
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  • Amentoflavone
    T34171617-53-4
    Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
    • $30
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  • BTA-9881
    T269141646857-24-0In house
    BTA-9881 is a novel RSV fusion inhibitor with oral activity and antiviral activity for the study of respiratory syncytial virus infections.
    • $80 TargetMol
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  • Rostafuroxin
    T2621156722-18-8
    Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.
    • $37
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    TargetMol | Citations Cited
  • Quercetin pentaacetate
    T383431064-06-8
    Quercetin pentaacetate (Pentaacetylquercetin) has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Quercetin pentaacetate interacts with RSV and inhibit the viral adhesion on cell surface.
    • $36
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  • RSV L-protein-IN-4
    T79220851657-60-8
    RSV L-protein-IN-4 (Compound C) is a noncompetitive inhibitor of the RSV polymerase with an IC50 of 0.88 μM. It demonstrates potent antiviral activity against RSV strains, with an EC50 of 0.25 μM [1].
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  • JNJ-8003
    T82005
    JNJ-8003 is a potent inhibitor of RSV Polymerase, effectively impeding the early stages of RNA transcription and replication by inhibiting nucleotide polymerization [1].
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  • RSV-IN-1
    T12774861139-16-4
    RSV-IN-1 is an inhibitor of human respiratory syncytical virus (hRSV) and reduced the virus infectivity with IC50 value of 0.11 μM.
    • $97
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  • Suptavumab
    T769921629615-23-1
    Suptavumab (REGN2222) is a human monoclonal antibody. Suptavumab neutralizes conserved epitopes on subtypes A and B on RSV. Suptavumab can be used to study RSV infections and the respiratory system.
    • $328
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  • Nirsevimab
    T771001989556-22-0
    Nirsevimab (MEDI8897) is a recombinant human respiratory syncytial virus (RSV) monoclonal antibody with a modified Fc region. Nirsevimab efficiently targets RSV-B with a Kd value of 1.5 nM. Nirsevimab can be used to prevent RSV infection.
    • $497
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  • KIN101
    T11760610753-87-2
    KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.
    • $47
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  • RSV L-protein-IN-3
    T79219868860-35-9
    RSV L-protein-IN-3 is an inhibitor of the wild-type RSV polymerase, exhibiting an IC50 of 10.4 μM and an EC50 of 2.1 μM (against RSV), and possesses lower cytotoxicity compared to the clinical agent Ribavirin [1].
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  • GS-443902
    T55391355149-45-9
    GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at least 12 weeks
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  • Palivizumab
    T76907188039-54-5
    Palivizumab (MEDI 493) is a humanized RSV-specific monoclonal antibody that selectively inhibits epitopes at the F protein A antigenic site of RSV subtypes A and B for the prevention of respiratory syncytial virus infection (RSV).
    • $228
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  • RSV L-protein-IN-2
    T79217774130-99-3
    RSV L-protein-IN-2 (Compound A), a noncompetitive inhibitor of the RSV polymerase (IC50: 4.5 μM), exhibits antiviral activity against long RSV strains (EC50: 1.3 μM) [1].
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  • AVG-233
    T632532151937-80-1
    AVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytial virus infections.
    • $1,400
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  • Lumicitabine
    TQ00341445385-02-3
    Lumicitabine (ALS-008176) is an inhibitor of RSV polymerase.
    • $347
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  • Ac-CoA Synthase Inhibitor1
    T4380508186-14-9
    Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).
    • $41
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  • RSV604
    T7353676128-63-5
    RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea) is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM)
    • $34
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  • Ziresovir
    T134011422500-60-4
    Ziresovir (RO-0529) is a respiratory syncytial virus fusion protein (RSV F) inhibitor that inhibits RSV activity and can be used in the study of syncytial virus sensing.
    • $173
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  • RSV L-protein-IN-5
    T79221851658-28-1
    RSV L-protein-IN-5 (Compound E) serves as a potent inhibitor of the Respiratory Syncytial Virus (RSV), with an EC50 value of 0.1 μM. It targets RSV polymerase with an IC50 of 0.66 μM and impedes RSV mRNA synthesis through the inhibition of transcript guanylation. The compound demonstrates moderate cytotoxicity, with a CC50 of 10.7 μM in HEp-2 cells, and effectively reduces viral titers in mouse models of RSV infection [1].
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  • 4-Methoxycinnamaldehyde
    TN30481963-36-6
    4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde) is an active ingredient of Agastache rugosa.4-Methoxycinnamaldehyde has cytoprotective activity against respiratory syncytial virus (RSV) in human laryngeal carcinoma cell lines, and helps to control disease induced by RSV infection, with an IC50 of approximately 0.055 μg/mL. The IC50 was about 0.055 μg/mL.
    • $39
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  • TMC353121
    T17107857066-90-1
    TMC353121 is a respiratory syncytial virus (RSV) fusion inhibitor with anti-RSV activity that inhibits the production of the inflammatory cytokines TNF-α, IL-6, and IL-1β, as well as chemokines, KC, IP-10, MCP, and MIP1-α.
    • $137
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  • Sisunatovir hydrochloride
    T91971903763-83-6
    Sisunatovir hydrochloride (RV521 HCl) is an orally available inhibitor of the RSV-F protein that has exhibited potent efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses in vitro (IC50 = 1.4 nM for RSV-A, IC50 = 1.0 nM for RSV-B).
    • $55
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  • Rilematovir
    T156211383450-81-4
    Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncytial virus treatment.
    • $40
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  • Presatovir
    TQ00851353625-73-6
    Presatovir (GS-5806) (GS-5806) is a novel, orally bioavailable RSV fusion inhibitor (mean EC50: 0.43 nM).
    • $97
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  • Enzaplatovir
    T272711323077-89-9
    Enzaplatovir (BTA-585) is an orally available fusion inhibitor with antiviral activity for the study of respiratory syncytial virus infections and coronavirus disease (COVID-19) infections.
    • $215
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  • ALS-8112
    T141951445379-92-9
    ALS-8112 (ALS 008112) is a selective and potent inhibitor of respiratory syncytial virus (RSV) polymerase with an IC50 value of 0.02 μM. ALS-8112 exhibits antiviral activity and inhibits the RNA polymerase activity of the RSV L-P protein complex through RNA chain termination. virus infections.
    • $139
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