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Anti-SOX-2 Polyclonal Antibody

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Catalog No. TMAB-01758
Alias Transcription factor SOX-2, SOX2

Anti-SOX-2 Polyclonal Antibody is a Rabbit antibody targeting SOX-2. Anti-SOX-2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.

Anti-SOX-2 Polyclonal Antibody

Anti-SOX-2 Polyclonal Antibody

😃Good
Catalog No. TMAB-01758Alias Transcription factor SOX-2, SOX2
Anti-SOX-2 Polyclonal Antibody is a Rabbit antibody targeting SOX-2. Anti-SOX-2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
Pack SizePriceAvailabilityQuantity
50 μL$2207-10 days
100 μL$3737-10 days
200 μL$5297-10 days
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Product Introduction

Bioactivity
Description
Anti-SOX-2 Polyclonal Antibody is a Rabbit antibody targeting SOX-2. Anti-SOX-2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
SynonymsTranscription factor SOX-2, SOX2
Ig Type
IgG
Reactivity
Mouse,Rat (predicted:Human,Chicken,Dog,Cow,Horse,Sheep)
Verified Activity
1. Paraformaldehyde-fixed, paraffin embedded Rat Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with SOX2 Polyclonal Antibody, Unconjugated (TMAB-01758) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining.
2. Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with SOX2 Polyclonal Antibody, Unconjugated (TMAB-01758) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining.
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundThis intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008].
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human SOX2
Antigen Species
Human
Gene Name
SOX2
Gene ID
Protein Name
Transcription factor SOX-2
Uniprot ID
Biology Area
Surface molecules,Germ cell markers,Leucine Zipper,HMG Box,Neural Stem Cell marker,Neural Signal Transduction,Neurogenesis,Intracellular,Embryonic Germ Cells
Function
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.
Chemical Properties
Molecular WeightTheoretical: 34 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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