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CRBN ligand-9

Name: CRBN ligand-9
Brand: TargetMol
SKU: T9360
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9360Cas No. 55003-81-1

Alias 2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione

CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) exhibit inhibition of CRBN.

CRBN ligand-9

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Purity: 99.88%

Catalog No. T9360Alias 2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dioneCas No. 55003-81-1

CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) exhibit inhibition of CRBN.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

CRBN ligand-9 AI Summary

CRBN ligand-9 inhibits the binding of MANT-uracil to the wild-type Magnetospirillum gryphiswaldense CRBN isoform 4, with a Ki value of 9000.0 nM, as demonstrated in a FRET assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) exhibit inhibition of CRBN.
Synonyms	2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione

Chemical Properties

Molecular Weight	303.23
Formula	C₁₃H₉N₃O₆
Cas No.	55003-81-1
Smiles	O=C1N(C(=O)C=2C1=CC(N(=O)=O)=CC2)C3C(=O)NC(=O)CC3
Relative Density.	1.651 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (214.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2978 mL	16.4891 mL	32.9783 mL	164.8913 mL
5 mM	0.6596 mL	3.2978 mL	6.5957 mL	32.9783 mL
10 mM	0.3298 mL	1.6489 mL	3.2978 mL	16.4891 mL
20 mM	0.1649 mL	0.8245 mL	1.6489 mL	8.2446 mL
50 mM	0.0660 mL	0.3298 mL	0.6596 mL	3.2978 mL
100 mM	0.0330 mL	0.1649 mL	0.3298 mL	1.6489 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc