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M‑89

Name: M‑89
Brand: TargetMol
SKU: T11925
Price: 169 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11925Cas No. 2363165-42-6

M-89, a highly potent and specific inhibitor of the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction, exhibits a Kd of 1.4 nM for menin binding. This compound holds potential for treating MLL leukemia.

M‑89

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Purity: 98.38%

Catalog No. T11925Cas No. 2363165-42-6

Pack Size	Price	Availability
1 mg	$169	In Stock
5 mg	$428	In Stock
10 mg	$591	In Stock
25 mg	$868	In Stock
50 mg	$1,180	In Stock
100 mg	$1,630	In Stock
1 mL x 10 mM (in DMSO)	$598	In Stock

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Batch Information

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Purity:98.38%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	M-89, a highly potent and specific inhibitor of the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction, exhibits a Kd of 1.4 nM for menin binding. This compound holds potential for treating MLL leukemia.
Targets&IC50	Menin-MLL:1.4 nM (kd)

Chemical Properties

Molecular Weight	657.87
Formula	C₃₇H₄₇N₅O₄S
Cas No.	2363165-42-6
Smiles	CNC(=O)O[C@H]1CCC[C@@H]1[C@@]1(CN(C)Cc2ccccc12)C1CCN(CC2CN(C2)c2ccc(cc2)S(=O)(=O)c2ccncc2)CC1
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 7 mg/mL (10.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5201 mL	7.6003 mL	15.2006 mL	76.0029 mL
5 mM	0.3040 mL	1.5201 mL	3.0401 mL	15.2006 mL
10 mM	0.1520 mL	0.7600 mL	1.5201 mL	7.6003 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc