Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NU223612 is a potent PROTAC (PROTACs) specifically targeting and degrading indoleamine 2,3-dioxygenase 1 (IDO1) (IDO)" style="display: inline; color: #c13a36">Indoleamine2,3-Dioxygenase(IDO)) via CRBN-mediated proteasomal degradation, demonstrating a binding affinity (Kd) of 640 nM for IDO1 and 290 nM for CRBN. Importantly, NU223612 is capable of crossing the blood-brain barrier (BBB) [1].
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Description | NU223612 is a potent PROTAC (PROTACs) specifically targeting and degrading indoleamine 2,3-dioxygenase 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) via CRBN-mediated proteasomal degradation, demonstrating a binding affinity (Kd) of 640 nM for IDO1 and 290 nM for CRBN. Importantly, NU223612 is capable of crossing the blood-brain barrier (BBB) [1]. |
Molecular Weight | 890.99 |
Formula | C49H55FN6O9 |
CAS No. | 2759420-43-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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NU223612 2759420-43-2 inhibitor inhibit