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Piromidic acid
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Catalog No. T16542Cas No. 19562-30-2
Piromidic acid is an antibacterial agent active against gram-negative bacteria and staphylococci, used for urinary tract and intestinal infections (Piromidic acid) [USP].
Piromidic acid
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Purity: 97.29%
Catalog No. T16542Cas No. 19562-30-2
Piromidic acid is an antibacterial agent active against gram-negative bacteria and staphylococci, used for urinary tract and intestinal infections (Piromidic acid) [USP].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $41 | In Stock | In Stock | |
| 50 mg | $82 | In Stock | In Stock | |
| 100 mg | $119 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.29%
Appearance:Solid
Color:White
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Product Introduction
Piromidic acid AI Summary
Piromidic acid is a versatile bioactive compound exhibiting cytotoxicity against human cancer cell lines and multiple other bioactivities. It has a Maximum Non-Toxic Concentration (MNTC) of 120.0 µM in HepG2 cells, 100.0 µM in HeLa cells, and 250.0 µM in CECH cells, with respective IC50 values of 110 µM, 97 µM, and 184 µM. It demonstrates inhibition of cell proliferation in various assays and has a cytotoxicity ratio of 1.67 for HepG2 cells.
In microbial assays, Piromidic acid shows an MIC of 38.0 µg/mL in Gyrase Induced DNA-Cleavage assays and IC50 greater than 100.0 µg/mL in a supercoiling inhibition assay for E. coli DNA gyrase. Its MIC values against bacteria are 50.0 µg/mL for E. coli (H560), 25.0 µg/mL for E. coli (vogel) and Klebsiella pneumonia (MGH-2), 12.5 µg/mL for Staphylococcus aureus (H228), and over 100.0 µg/mL for Pseudomonas aeruginosa (UI-18) and Streptococcus pneumoniae (SV-1).
The compound also displays 25.0% relaxation in isolated guinea pig trachea and a pD2 value of 5.3 for relaxation potency. In various enzymatic and cell-based assays, it demonstrates potencies ranging from 707.9 nM to over 25,000 nM, with notable activities including the inhibition of Lamin A splicing, Caspase-1, GCN5L2, APE1, and Ebola virus entry.
Piromidic acid inhibits sodium fluorescein uptake significantly in OATP1B1 and OATP1B3-transfected CHO cells, with an inhibition rate of 79.57% and 100.95% respectively at 10 µM, indicating strong OATP inhibitor potential. It has low inhibition of cell viability with an inhibition index of 0.06078.
In antiviral assays, the compound shows varied inhibition of SARS-CoV-2 induced cytotoxicity and 3CL-Pro protease, with some results indicating low or negligible effects at tested concentrations. However, it exhibits potential as a protease inhibitor with 8.107% inhibition of SARS-CoV-2 3CL-Pro at 20 µM and IC50 values greater than 20000.0 nM in certain assays.
Additionally, Piromidic acid has potential HDAC6 inhibitory activity with inhibition percentages of -15.55% in commercial peptide substrate assays and -8.29% in custom peptide substrate assays. It also shows antimalarial activity with IC50 values of 21.6 µg/mL in hepatic stage and 14.4 µg/mL and 41.4 µg/mL in blood stages for different strains of Plasmodium.
Overall, these results suggest Piromidic acid has a diverse range of bioactivities, making it a compound of interest for further research in oncology, antimicrobial, antiviral, and antimalarial fields, as well as in OATP and HDAC6 inhibition studies..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Piromidic acid is an antibacterial agent active against gram-negative bacteria and staphylococci, used for urinary tract and intestinal infections (Piromidic acid) [USP]. |
| Molecular Weight | 288.3 |
| Formula | C14H16N4O3 |
| Cas No. | 19562-30-2 |
| Smiles | CCn1cc(C(O)=O)c(=O)c2cnc(nc12)N1CCCC1 |
| Relative Density. | 1.4g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (insoluble or slightly soluble) H2O: 1 mg/mL (3.47 mM), Sonication and heating to 80℃ are recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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