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NVP-LCQ195

Name: NVP-LCQ195
Brand: TargetMol
SKU: TQ0068
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0068Cas No. 902156-99-4

Alias LCQ-195, AT9311

NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).

NVP-LCQ195

😃Good

Purity: 99.85%

Catalog No. TQ0068Alias LCQ-195, AT9311Cas No. 902156-99-4

NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$148	In Stock	In Stock
25 mg	$283	In Stock	In Stock
50 mg	$416	In Stock	In Stock
100 mg	$593	In Stock	In Stock
200 mg	$783	-	In Stock
1 mL x 10 mM (in DMSO)	$100	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
Targets&IC50	CDK9-CyclinT1:15 nM, CDK2-CyclinE:5 nM, CDK5-p25:1 nM, CDK2-CyclinA:2 nM, CDK3-CyclinE:42 nM, CDK6-CyclinD3:187 nM, CDK5-p35:1 nM, CDK7-CyclinH-MAT1:3564 nM, CDK1-CyclinB:2 nM
In vitro	NVP-LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-1 mol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. In MM cells, LCQ195 triggered decreased amplitude of transcriptional signatures associated with oncogenesis, drug resistance and stem cell renewal, including signatures of activation of key transcription factors for MM cells e.g. myc, HIF-1a, IRF4[1].
In vivo	Bortezomib-treated MM patients whose tumours had high baseline expression of genes suppressed by LCQ195 had significantly shorter progression-free and overall survival than those with low levels of these transcripts in their MM cells[1].
Synonyms	LCQ-195, AT9311

Chemical Properties

Molecular Weight	460.33
Formula	C₁₇H₁₉Cl₂N₅O₄S
Cas No.	902156-99-4
Smiles	CS(=O)(=O)N1CCC(CC1)NC(=O)c1[nH]ncc1NC(=O)c1c(Cl)cccc1Cl
Relative Density.	1.57 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (217.24 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1724 mL	10.8618 mL	21.7235 mL	108.6177 mL
5 mM	0.4345 mL	2.1724 mL	4.3447 mL	21.7235 mL
10 mM	0.2172 mL	1.0862 mL	2.1724 mL	10.8618 mL
20 mM	0.1086 mL	0.5431 mL	1.0862 mL	5.4309 mL
50 mM	0.0434 mL	0.2172 mL	0.4345 mL	2.1724 mL
100 mM	0.0217 mL	0.1086 mL	0.2172 mL	1.0862 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc