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PF-06751979

Name: PF-06751979
Brand: TargetMol
SKU: T12429
Rating: 4.5 (1 reviews)

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Catalog No. T12429Cas No. 1818339-66-0

PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).

PF-06751979

😃Good

Catalog No. T12429Cas No. 1818339-66-0

PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,230	10-14 weeks	10-14 weeks
50 mg	$1,610	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
Targets&IC50	BACE1:7.3 nM , BACE2:194 nM
In vitro	PF-06751979 demonstrates enhanced selectivity for BACE2 (IC50=194 nM) with a 27-fold improvement compared to literature examples and various chemical series in the BACE1 program.
In vivo	PF-06751979 demonstrates excellent brain penetration, potent in vivo efficacy, and broad selectivity over related aspartyl proteases, including BACE2. Acute administration results in a robust, dose-responsive, and time-dependent reduction of cerebral spinal fluid (CSF) Aβx-40, with peak inhibition of over 77% at 3 hours. [1].

Chemical Properties

Molecular Weight	455.5
Formula	C₁₈H₁₉F₂N₅O₃S₂
Cas No.	1818339-66-0
Relative Density.	1.66 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 50 mg/mL (109.77 mM), Sonication is recommended.

DMSO: 150 mg/mL (329.31 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1954 mL	10.9769 mL	21.9539 mL	109.7695 mL
5 mM	0.4391 mL	2.1954 mL	4.3908 mL	21.9539 mL
10 mM	0.2195 mL	1.0977 mL	2.1954 mL	10.9769 mL
20 mM	0.1098 mL	0.5488 mL	1.0977 mL	5.4885 mL
50 mM	0.0439 mL	0.2195 mL	0.4391 mL	2.1954 mL
100 mM	0.0220 mL	0.1098 mL	0.2195 mL	1.0977 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc